Du Research Group

 

 

98

Zhang W, Zhao B, Du L, and Shen Y. 2017. Cytotoxic polyketides with an oxygen-bridged cyclooctadiene core skeleton from the mangrove endophytic fungus Phomosis sp. A818. Molecules 22, 1547. doi:10.3390/molecules22091547. (Invited for the Special Issue in Honor of Professor Thomas James Simpson on the Occasion of His 70th Birthday)

97

Li S, Wu X, L Zhang, Shen Y, and Du L. 2017. Activation of a cryptic gene cluster in Lysobacter enzymogenes revealed a module/domain portable mechanism of nonribosomal peptide synthetases in the biosynthesis of pyrrolopyrazines. Organic Letters in press. 10.1021/acs.orglett.7b01611.

96

Zhang W, Huffman J, Li S, Shen Y, and Du L. 2017. Unusual acylation of chloramphenicol in Lysobacter enzymogenes, a biocontrol agent with intrinsic resistance to multiple antibiotics. BMC Biotechnology 17: 59. pdf

95

Han Y, Wang Y, Yu Y, Chen H, Shen Y, and Du L. 2017. Indole-induced reversion of intrinsic multi-antibiotic resistance in Lysobacter enzymogenes. Applied and Environmental Microbiology 83:e00995-17. pdf.

94

Zhao Y, Qian G, Chen Y, Du L, and Liu F. 2017.  Transcriptional and antagonistic responses of biocontrol strain Lysobacter enzymogenes OH11 to the plant pathogenic oomycete Pythium aphanidermatum. Frontiers in Microbiology 8: 1025. pdf

93

Su Z, Chen H, Wang P, Tombosa S, Du L, Han Y, Shen Y, Qian G, and Liu F. 2017.  4-Hydroxybenzoic acid is a diffusible factor that connects metabolic shikimate pathway to the biosynthesis of a unique antifungal metabolite in Lysobacter enzymogenes. Molecular Microbiology 104: 163-178. pdf

92

Zawatzky K, Reibarkh M, Canfield N, Wang TC, Li S, Du L, Welch CJ. 2016.  Visualizing small differences using subtractive chromatographic analysis. Journal of Chromatography A 1468: 245-249. pdf

91

Xu G, Shi X, Wang R, Xu H, Du L, Chou SH, Liu H, Liu Y, Qian G, and Liu F. 2016.  Insights into the distinct cooperation between the transcription factor Clp and LeDSF signaling in the regulation of antifungal factors in Lysobacter enzymogenes OH11. Biological Control accepted

90

Ding Y, Li Y, Li Z, Zhang J, Lu C, Wang H, Shen Y, and Du L. 2016. Alteramide B is a microtubule antagonist of inhibiting Candida albicans. Biochimica et Biophysica Acta – General Subjects 1860:2097-2106. pdf

89

Zhao Y, Qian G, Ye Y, Wright S, Chen H, Shen Y, Liu F, and Du L. 2016. Heterocyclic aromatic N-oxidation in the biosynthesis of phenazine antibiotics from Lysobacter antibioticus. Organic Letters 18: 2495-2498. pdf

88

Xu H, Chen H, Shen Y, Du L, Chou SH, Liu L, Qian G, and Liu F. 2016. Direct regulation of extracellular chitinase production by the transcription factor LeClp in Lysobacter enzymogenes OH11. Phytopathology 106: 971-977. pdf

87

Wang R, Xu H, Du L, Chou SH, Liu H, Liu Y, Liu F, and Qian G. 2016. A TonB-dependent receptor regulates antifungal HSAF biosynthesis in Lysobacter. Scientific Reports  6: 26881. pdf

86

Wang M, Zhang W, Xu W, Shen Y, and Du L. 2016. Optimization of genome shuffling for high yield production of the antitumor deacetylmycoepoxydiene in an endophytic fungus of mangrove plants. Applied Microbiology and Biotechnology 100: 7491–7498. pdf

85

Ding Y, Li Z, Li Y, Lu C, Wang H, Shen Y, and Du L. 2016. HSAF-induced antifungal effects in Candida albicans through ROS-mediated apoptosis. RSC Advances 6: 30895-30904. pdf

84

Chen H and Du L. 2016. Iterative polyketide biosynthesis by modular polyketide synthases in bacteria. Applied Microbiology and Biotechnology 100: 541-557. pdf

83

Chen H, Olson AS, Su W, Dussault PH, and Du L. 2015. Fatty acyl incorporation in the biosynthesis of WAP-8294A, a group of potent anti-MRSA cyclic lipodepsipeptides. RSC Advances 5: 105753-105759. pdf

82

Xu L, Wu P, Wright S, Du L, and Wei X. 2015. Bioactive polycyclic tetramate macrolactams from Lysobacter enzymogenes and their absolute configurations by theoretical ECD calculations. J Nat Prod 78: 1841-1847. pdf

81

Zhou X, Qian G, Chen Y,  Du L, Liu F, and Yuen G. 2015. PilG is involved in the regulation of twitching motility and antifungal antibiotic biosynthesis in the biological control agent Lysobacter enzymogenes. Phytopathology. 105:1318-1324. pdf

80

Yang Y, Liu B, Du X, Li P, Liang B, Cheng X, Du L, Huang D, Wang L, and Wang S. 2015. Complete genome sequence and transcriptomics analyses reveal pigment biosynthesis and regulatory mechanisms in an industrial strain, Monascus purpureus YY-1. Scientific Reports 5:8331. pdf

79

Olson AS, Chen H, Du L, and Dussault PH. 2015. Synthesis of a 2,4,6,8,10-dodecapentanoic acid thioester as a substrate for biosynthesis of Heat Stable Antifungal Factor (HSAF). RSC Advances 5: 11644-11648. pdf

78

Xu G, Zhao Y, Du L, Qian G, and Liu F. 2015. Hfq regulates antibacterial antibiotic biosynthesis and extracellular lytic-enzyme production in Lysobacter enzymogenes OH11. Microbial Biotechnology 8: 499–509. pdf.

77

Han Y, Wang Y, Tombosa S, Wright S, Huffman J, Yuen G, Qian G, Liu F, Shen Y, and Du L. 2015. Identification of a small molecule signaling factor that regulates the biosynthesis of the antifungal polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes. Applied Microbiology and Biotechnology 99: 801-811. pdf

76

Wang Y, Zhao Y, Zhang J,  Zhao Y, Shen Y, Su Z, Xu G, Du L, Huffman J, Venturi V, and Qian G, and Liu F. 2014. Transcriptomic analysis reveals new regulatory roles of Clp signaling in secondary-metabolite biosynthesis and surface motility in Lysobacter enzymogenes OH11. Applied Microbiology and Biotechnology 98: 9009-9020. pdf

75

Zhang J, Du L, Liu F, Xu F, Hu B, Venturi V, and Qian G. 2014. Involvement of both PKS and NRPS in antibacterial activity in Lysobacter enzymogenes OH11. FEMS Microbiol Lett 355:170-176. pdf

74

Li Y, Chen H, Ding Y, Xie Y, Wang H, Cerny RL, Shen Y, and Du L. 2014. Iterative assembly of two separate polyketide chains by the same single-module bacterial polyketide synthase in the biosynthesis of HSAF. Angew Chem Int Ed 53: 7524-7530. pdf

73		Qian G, Xu F, Venturi V, Du L, and Liu F. 2014. Roles of a solo LuxR in the biological control agent Lysobacter enzymogenes strain OH11. Phytopathology 104:224-231. pdf (Editor’s Pick of the March issue of Phytopathology, March 12, 2014, pdf)

72		Li Y, Lou L, Cerny RL, Butchko RAE, Proctor RH, Shen Y, and Du L. 2013. Tricarballylic ester formation during biosynthesis of fumonisin mycotoxins in Fusarium verticillioides. Mycology 4: 179-186. pdf
71		Qian G, Wang Y, Liu Y, Xu F, He Y, Venturi V, Du L, Fan J, Hu B, and Liu F. 2013. Lysobacter enzymogenes uses two distinct cell-cell signaling systems for differential regulation of secondary metabolite biosynthesis and colony morphology. Appl Environ Microbiol 79: 6604-6616. pdf
70		Wang Y, Qian G, Liu F, Li Y-Z, Shen Y, and Du L. 2013. Facile method for site-specific gene integration in Lysobacter enzymogenes for yield improvement of the anti-MRSA antibiotics WAP-8294A and the antifungal antibiotic HSAF. ACS Synthetic Biology 2: 670-678. pdf
69		Wang Y, Qian G, Li Y, Wang YS, Wang YL, Wright S, Li Y-Z, Shen Y, Liu F, and Du L. 2013. Biosynthetic mechanism for sunscreens of the biocontrol agent Lysobacter enzymogenes. PLOS One 8(6): e66633. pdf
68		Zhao PJ, Yang YL, Du L, Liu JK, and Zeng Y. 2013. Elucidating the biosynthetic pathway for vibralactone: A pancreatic lipase inhibitor with a fused bicyclic ß-lactone. Angew Chem Int Ed 52: 1-6. pdf
67		Xie Y, Wright S, Shen Y, and Du L. 2012. Bioactive natural products from Lysobacter. Nat Prod Rep 29: 1277-1287. pdf
66		Gonzalez DJ. Xu Y, Yang Y, Esquenazi E, Liu W, Edlund A, Duong T, Du L, Molnár I, Gerwick WH, Jensen PR, Fischbach M, Liaw C, Straight P, Dixon JE, Nizet V, and Dorrestein PC. 2012. Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange capacity of microbes. J Proteomics 75: 5069-5076. pdf
65		Li Y, Huffman J, Li Yu, Du L and Shen Y. 2012. 3-Hydroxylation of the polycyclic tetramate macrolactam in the biosynthesis of antifungal HSAF fromLysobacter enzymogenes C3. MedChemComm 3: 982-986. pdf
64		Lou L, Chen H, Cerny RL, Li Y, Shen Y, and Du L. 2012. Unusual activities of the thioesterase domain for the biosynthesis of the polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes C3. Biochemistry 51, 4-6. pdf (Highlighted on Biochemistry website, January, 2012).
63		Xu W, Zhu H, Tan N, Tang J, Zhang Y, Cerny RL, and Du L. 2012. An in vitro system to heterophyllin B biosynthesis in the medicinal plant Pseudostellaria heterophylla. Plant Cell, Tissue & Organ Culture 108: 137-145. pdf
62		Zhang W, Li Y, Qian G, Wang Y, Chen H, Li Y-Z, Liu F, Shen Y, and Du L. 2011. Identification and characterization of the Anti-Methicillin-ResistantStaphylococcus aureus WAP-8294A2 biosynthetic gene cluster from Lysobacter enzymogenes OH11. Antimicrobial Agents and Chemotherapy 55, 5581-5589. pdf.
61		Xu W, Li L, Du L, and Tan N. 2011. Various mechanisms in cyclopeptide production from precursors synthesized independently of nonribosomal peptide synthetases. Acta Biochimica et Biophysica Sinica. 43: 757-762. pdf.
60		Hage DS, Dodds ED, Du L, and Powers R. 2011. Research in bioanalytical separations and related techniques at the Department of Chemistry, University of Nebraska. Bioanalysis 3: 1065-1076. pdf.
59		Xie Y, Zhang W, Li Y, Wang M, Cerny RL, Shen Y, and Du L. 2011. Transformation of Fusarium verticillioides with a polyketide gene cluster isolated from a fungal endophyte activates the biosynthesis of fusaric acid. Mycology 2: 24-29. pdf
58		Du L, Che Y and Oh H (Editors) 2011. Fungal Metabolites—Structures, Activities and Biosynthesis. Mycology 2 (1). pdf
57		Lou L, Qian G, Xie Y, Hang J, Chen H, Zaleta-Rivera K, Li Y, Shen Y, Dussault PH, Liu F, and Du L. 2011. Biosynthesis of HSAF, a tetramic acid-containing macrolactam from Lysobacter enzymogenes. Journal of American Chemical Society133: 643-645. pdf
56		Fan JT, Chen YS, Xu WY, Du L, Zeng GZ, Zhang YM, Su J, Li Y, and Tan NY. 2010. Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis. Tetrahedron Letters 51: 6810-6813. pdf
55		Huffman J, Gerber R, and Du L. 2010. Recent advancements in the biosynthetic mechanisms for polyketide-derived mycotoxins. Biopolymers, 93: 764-776. pdf
54		Wang J, Wang X, Zhou Y, Du L, and Wang Q. 2010. Fumonisin detection and analysis of potential fumonisin-producing Fusarium spp. in asparagus (Asparagus officinalis L.) in Zhejiang Province of China. J Science of Food and Agriculture 90: 836-842. pdf
53		Du L and Lou L. 2010. PKSs and NRPSs releasing mechanisms. Nat Prod Rep 27: 255-278. pdf
52		Du L, Tan N, Xu W, and Lou L. 2009. Plant cyclopeptides and possible biosynthetic mechanisms. Acta Botanica Yunnanica 31: 374-382. pdf
51		Li Y, Shen, Y, Zhu X, and Du L. 2009. Introduction of the AAL-toxin polyketide synthase gene ALT1 into FUM1-disrupted Fusarium verticillioidesproduces metabolites with the fumonisin methylation pattern. J Nat Prod 72: 1328-1330. pdf
50		Gerber R, Lou L, Huffman J, Zhu X, Lin T, Li Q, Arreguin I, Butchko RAE, Proctor RH, and Du L. 2009. Advances in Understanding the biosynthesis of fumonisins. Mycotoxin Prevention and Control in Agriculture (M Appell, DF Kendra, MW Trucksess, eds.), Vol 1031, Chapter 12, pp 167-182, ACS, Washington, D. C. pdf
49		Li S, Calvo AM, Yuen G, Du L, and Harris SD. 2009. Induction of cell wall thickening by the antifungal compound HSAF disrupts fungal growth and is mediated by sphingolipid biosynthesis. J Eukaryotic Microbiology 56: 182-187. pdf
48		Gerber R, Lou L, and Du L. 2009. A PLP-dependent polyketide chain releasing mechanism in the biosynthesis of mycotoxin fumonisins in Fusarium verticillioides. Journal of American Chemical Society 131:3148-3149. pdf Featured on JACS website, March 2009.
47		Zhu X, Vogeler C, and Du L. 2008. Functional complementation of fumonisin biosynthesis in FUM1-disrupted Fusarium verticillioides by the AAL-toxin polyketide synthase gene ALT1 from Alternaria alternata f. sp. Lycopersici. J Natural Products 71:957-960. pdf
46		Zhu X, Huffman J, Gerber R, Lou L, Xie Y, Lin T, Jorgenson J, Maresch A, Vogeler C, Wang Q, Shen Y, and Du L. 2008. Biosynthesis and genetic engineering of polyketides. Acta Botanica Yunnanica 30: 249-278 (invited on the occasion of the 30th anniversary of the Journal) pdf
45		Li S, Jochum CC, Yu F, Zaleta-Rivera K, Du L, Harris SD, and Yuen G. 2008. An antifungal secondary metabolite from Lysobacter enzymogenes strain C3: isolation, biological activity and potential use in plant disease control. Phytopathology 98: 695-701. pdf
44		Du L, Zhu X, Gerber R, Huffman J, Lou L, Jorgenson J, Yu F, Zaleta-Rivera K, and Wang Q. 2008. Biosynthesis of sphinganine-analog mycotoxins. J Industrial Microbiology & Biotechnology 35: 455-464. pdf
43		Wang J, Zhou Y, Liu W, Zhu X, Du L, and Wang Q. 2008. Fumonisin level in corn-based food and feed from Linxian County: a high-risk area for esophageal cancer in China. Food Chemistry 106: 241-246. pdf
42		Zhu X, Yu F, Li X-C, and Du L. 2007. Production of dihydroisocoumarins in Fusarium verticillioides by swapping the ketosynthase domain of the fungal iterative modular polyketide synthase Fum1p with that of lovastatin diketide synthase. Journal of American Chemical Society 129: 36-37. pdf
41		Yu F, Zaleta-Rivera K, Zhu X, Huffman J, Millet J, Harris SD, Yuen G, Li X, and Du L. 2007. Structure and biosynthesis of HSAF, a broad spectrum antimycotic with a novel mode of action. Antimicrobial Agents and Chemotherapy 51: 64-72. pdf Cited by Faculty of 1000 Biology. pdf
40		Du L. Yu F, Zhu X, Zaleta-Rivera K, Bojja RS, Ding Y, Yi H, and Wang Q. 2007. Biochemical and molecular analysis of the biosynthesis of fumonisins. Polyketides: Biosynthesis, Biological Activities and Genetic Engineering (AM Rimando and SR Baerson, ed.) ACS Symposium Series 955, ACS, Washington, D. C., pp 81-96. pdf
39		Zhu X, Yu F, Bojja RS, Zaleta-Rivera K, and Du L. 2006. Functional replacement of the ketosynthase domain of FUM1 for the biosynthesis of fummonisins, mycotoxins with a reduced polyketide chain. J Industrial Microbiology & Biotechnology 33: 859-868. pdf
38		Zaleta-Rivera K, Xu C, Yu F, Butchko RAE, Proctor RH, Lara MEH, Raza A, Dussault PH, and Du L. 2006. A bidomain nonribosomal peptide synthetase encoded by FUM14 catalyzes the formation of tricarballylic esters in the biosynthesis of fumonisins. Biochemistry 45: 2561-2569. pdf.
37		Li S, Du L, Yuen G, and Harris SD. 2006. Distinct ceramide synthases regulate polarized growth in the filamentous fungus Aspergillus nidulans. Mol Biol Cell 17: 1218-1227. Cited by Faculty of 1000 Biology. pdf
36		Xu L and Du L. 2006. Direct detection and quantification of Alternaria alternata lycopersici toxins using high-performance liquid chromatography-evaporative light-scattering detection. J Microbiology Methods 64: 398-405. pdf
35		Wang Q, Wang J, Yu F, Zhu X, Zaleta-Rivera K, and Du L. 2006. Mycotoxin fumonisins: Health impacts and biosynthetic mechanism. Progress in Natural Science 16: 7-15. pdf
34		Yu F, Zhu X, and Du L. 2005. Developing a genetic system for functional manipulations of FUM1, a polyketide synthase gene for the biosynthesis of fumonisins in Fusarium verticillioides. FEMS Microbiology Letters 248: 257-264. pdf
33		Yi H, Bojja RS, Fu J, and Du L. 2005. Direct evidence for the function of FUM13 in 3-ketoreduction of mycotoxin fumonisins in Fusarium verticillioides. J Agricultural and Food Chemistry 53: 5456-5460. pdf
32		Shen B, Chen M, Cheng Y, Du L, Edwards D, George NP, Huang Y, Oh T, Sanchez C, Tang G, Wendt-Pienkowski E, and Yi F. 2005. Prerequisites for combinatorial biosynthesis: evolution of hybrid NRPS/PKS gene clusters. Ernst Schering Res Found Workshop 51: 107-126. pdf
31		Bojja RS, Cerny R, Proctor RH, and Du L. 2004. Determining the biosynthetic sequence in the early steps of the fumonisin pathway by use of three gene-disruption mutants of Fusarium verticillioides. J Agricultural and Food Chemistry 52: 2855-2860. pdf
30		Ding Y, Bojja RS, and Du L. 2004. Fum3p, a 2-ketoglutarate dependent dioxygenase, is required for C-5 hydroxylation of fumonisins in Fusarium verticillioides. Applied and Environmental Microbiology 70: 1931-1934. pdf
29		Du L, Chen M, Zhang Y, and Shen B. 2003. BlmIII and BlmIV nonribosomal peptide synthetase-catalyzed biosynthesis of the bleomycin bithiazole moiety involving both in cis and in trans aminoacylation. Biochemistry 42: 9731-9740.
28		Du L, Cheng YQ, Ingenhorst G, Tang GL, Huang Y, and Shen B. 2003. Hybrid peptide-polyketide natural products: biosynthesis and prospects towards engineering novel molecules. In Genetic Engineering, Vol. 25, Setlow, JK ed, Kluwer Academic/Plenum Publishers, pp227-267.
27		Shen B, Du L, Sanchez C, Edwards D, Chen M, and Murrell JM. 2002. Cloning and characterization of the bleomycin biosynthetic gene cluster fromStreptomyces verticillus ATCC15003. J Natural Products 65: 422-431.
26		Shen B, Du L., Sanchez C, Edwards D, Chen M, and Murrell JM. 2001. The biosynthetic gene cluster for the anticancer drug bleomycin fromStreptomyces verticillus ATCC 15003 as a model for hybrid peptide-polyketide natural product biosynthesis. J Industrial Microbiology & Biotechnology 27: 378-385.
25		Hansen CH, Du L, Naur P, Olsen CE, Axelsen KB, Hick AJ, Pickett JA, and Halkier BA. 2001. The oxime-metabolizing enzyme CYP83B1 in the glucosinolate pathway is related to the oxime-metabolizing enzyme in the cyanogenic glucoside pathway. J Biological Chemistry 276: 24790-24796.
24		Sanchez C, Du L, Edwards D, and Shen B. 2001. Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillusATCC 15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin. Chemistry & Biology 8: 725-738.
23		Du L and Shen B. 2001. Biosynthesis of hybrid peptide-polyketide natural products. Current Opinion in Drug Discovery and Development 4: 215-228.
22		Du L, Sanchez C, and Shen B. 2001. Hybrid peptide-polyketide natural products: biosynthesis and prospects towards engineering novel molecules. Metabolic Engineering 3: 78-95.
21		Shen B, Du L, Sanchez C, Chen M, and Edwards DJ. 2000. Bleomycin gene cluster components and their uses, WIPO patent number WO 040704, issued on July 13, 2000.
20		Du L, Sanchez C, Chen M, Edwards D, and Shen B. 2000. The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase. Chemistry & Biology 7: 623-642. Featured in C & E News, 2000, 78, 33.
19		Du L, Chen M, Sanchez C, and Shen B. 2000. An oxidation domain in nonribosomal peptide synthetases probably catalyzing the formation of thiazoles in the biosynthesis of antitumor drug bleomycin. FEMS Microbiology Letters 189:171-175.
18		Shen Y, Gan F, Du L, Hao X.  2000. Biosynthesis of polyketides. Huaxue Jinzhan,  12: 401-408.
17		Du L and Shen B. 1999. Identification and characterization of a type-II peptidyl carrier protein (PCP) from Streptomyces verticillus ATCC 15003.Chemistry & Biology 6: 507-517
16		Shen B, Du L, Sanchez C, Chen M, Edwards D. 1999. Bleomycin biosynthesis in Streptomyces verticillus ATCC 15003: a model of hybrid peptide and polyketide biosynthesis. Bioorganic Chemistry 27: 155-177.
15		Du L and Halkier BA. 1998. Biosynthesis of glucosinolates in the developing silique walls and seeds of Sinapis alba L. Phytochemistry 48: 1145-1150.
14		Halkier BA and Du L. 1997. The biosynthesis  of glucosinolates. The Trends in Plant Science 2: 425-431.
13		Du L and Halkier BA. 1997. Involvement of cytochrome P450 in oxime production in glucosinolate biosynthesis. in Sulphur Metabolism in Higher Plants. Molecular, Ecophysiological, and Nutritional Aspects (eds. Cram, WJ, et al.). Backhuys Publishers, Leiden. The Netherlands, pp. 271-274.
12		Du L and Halkier BA. 1996. Isolation of a microsomal enzyme system involved in glucosinolate biosynthesis from seedlings of Tropaeolum majus L. Plant Physiology 111: 831-837.
11		Du L, Lykkesfeldt J, Olsen C, Halkier BA. 1995.  Involvement of cytochrome P450 in oxime production in glucosinolate biosynthesis as demonstrated by an in vitro microsomal enzyme system isolated from jasmonic acid-induced seedlings of Sinapis abla L. Proc Natl Acad Sci USA 92: 12505-12509.
10		Du L, Bokanga M, Møller BL, Halkier BA. 1995. The biosynthesis of cyanogenic glucosides in roots of cassava. Phytochemistry 39: 323-327.

Earlier publications are in Chinese.

 

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