Publications
| 127 | Miller A, Li S, Eichhorn CD, Zheng Y, and Du L. 2023. Identification and biosynthetic study of the siderophore lysochelin in the biocontrol Agent Lysobacter enzymogenes. Journal of Agricultural and Food Chemistry 71: 7418-7426. pdf
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| 126 | Li X, Liu Q, Zou H, Luo J, Jiao Y, Wang H, Du L, Shen Y, and Li Y. 2023. Discovery and biosynthesis of pseudoamides reveals enzymatic cyclization of the polyene precursor to 5-5 bicyclic tetramate macrolactams. ACS Catalysis 13: 4760-4767. pdf |
| 125 | Han W, Zhai Y, Zhang R, Gong X, Li J, Xu G, Lei X, Du L, and Gao J. 2023. Tricrilactones A−H, potent antiosteoporosis macrolides with distinctive ring skeletons from Trichocladium crispatum, an alpine moss-associated fungus. Angewandte Chemie International Edition 62: e202300773. pdf |
| 124 | Zhu Y, Dou Q, Du L, and Wang Y. 2023. QseB/QseC: a two-component system globally regulating bacterial behaviors. Trends in Microbiology 31: 749-762. pdf |
| 123 | Yue H and Du L. 2023. Function of a pathway-associated major facilitator superfamily gene hsaf-orf1 in the biosynthesis of the antifungal HSAF in Lysobacter enzymogenes. Tetrahedron 130: 133173. pdf
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| 122 | Luo J, Li X, Wang H, Du L, Shen Y, and Li Y. 2022. Identification and characterization of the 28-N-methyltransferase involved in HSAF analogue biosynthesis. Biochemistry 61:2879-2883. pdf |
| 121 | Khetrapal V, Dussault P, and Du L. 2022. Biosynthesis of odd-carbon unsaturated fatty dicarboxylic acids through engineering the HSAF biosynthetic gene in Lysobacter enzymogenes. Molecular Biotechnology 64: 1401–1408. pdf |
| 120 | Zhong J, Yan X, Zuo X, Zhao X, Yang J, Dou Q, Peng L, Zhu Y, Xiao Y, Bian Z, He D, Xu Q, Wright S, Li Y, Du L, Wang Y, and Yuan J. 2022. Developing a new treatment for superficial fungal infection using antifungal collagen-HSAF dressing. Bioengineering & Translational Medicine 7:e10304. pdf |
| 119 | Yue H, Miller A, Khetrapal V, Jayasekera V, Wright S, and Du L. 2022. Biosynthesis, regulation, and engineering of natural products from Lysobacter. Natural Product Reports 39: 842 – 874. pdf |
| 118 | Failor K, Liu H, Llontop M, LeBlanc S, Eckshtain-Levi N, Sharma P, Reed A, Yang S, Tian L, Lefevre C, Menguy N, Du L, Monteil C, and Vinatzer B. 2022. Ice nucleation in a Gram-positive bacterium isolated from precipitation depends on a polyketide synthase and non-ribosomal peptide synthetase. ISME Journal 16: 890–897. pdf. |
| 117 | Zhu J, Chen Y, and Du L. 2022. Production of new WAP-8294A cyclodepsipeptides in the biocontrol agent Lysobacter enzymogenes OH11. Frontiers of Agricultural Science and Engineering 9: 120-132. pdf
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| 116 | Yue H, Jiang J, Taylor A, Leite A, Dodds E, and Du L. 2021. Outer membrane vesicles-mediated co-delivery of the antifungal HSAF metabolites and lytic polysaccharide monooxygenase in the predatory Lysobacter enzymogenes. ACS Chemical Biology 16: 1079-1089. pdf
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| 115 | Yu L, Li H, Zhou Z, Liu F, and Du L. 2021. An antifungal polycyclic tetramate macrolactam HSAF is a novel oxidative stress modulator in Lysobacter enzymogenes. Applied and Environmental Microbiology 87: e03105-20. pdf
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| 114 | Yu L, Du F, Chen X, Zheng Y, Morton M, Liu F, and Du L. 2020. Identification of the biosynthetic gene cluster for the anti-MRSA lysocins through gene cluster activation using strong promoters of housekeeping genes and production of new analogs in Lysobacter sp. 3655. ACS Synthetic Biology 9: 1989-1997. pdf
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| 113 | Yu L, Khetrapal V, Liu F, and Du L. 2020. LeTetR positively regulates 3-hydroxylation of the antifungal HSAF and its analogs in Lysobacter enzymogenes OH11. Molecules 25: 2286. pdf |
| 112 | Bai N, Li G, Luo S, Du L, Hu Q, Xu H, Zhang K, and Zhao P. 2020. Vib-PT, an aromatic prenyltransferase involved in the biosynthesis of vibralactone from Stereum vibrans. Applied and Environmental Microbiology 86: e02687-19. pdf |
| 111 | Yu M, Zhang G, Jiang J, Du L, and Zhao Y. 2020. Lysobacter enzymogenes employs diverse genes for inhibiting hyphae growth and spore germination of soybean fungal pathogens. Phytopathology 110: 593-602. pdf |
| 110 | Feng T, Han Y, Li B, Li Z, Yu Y, Sun Q, Li X, Du L, Zhang XH, and Wang Y. 2019. Interspecies and intraspecies signals synergistically regulate the twitching motility in Lysobacter enzymogenes. Applied and Environmental Microbiology 85: e01742-19. pdf |
| 109 | Chen X, Li S, Yu L, Miller A, and Du L. 2019. Systematic optimization for production of the anti-MRSA antibiotics WAP-8294A in an engineered strain of Lysobacter enzymogenes. Microbial Biotechnology 12:1430–1440. pdf |
| 108 | Sang M, Wang H, Shen Y, Rodrigues de Almeida N, Conda-Sheridan M, Li S, Li Y, and Du L. 2019. Identification of an anti-MRSA cyclic lipodepsipeptide, WBP-29479A1, by genome mining of Lysobacter antibioticus. Organic Letters 21: 6432-6436. pdf
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| 107 | Li X, Wang H, Shen Y, Li Y, and Du L. 2019. OX4 is an NADPH-dependent dehydrogenase catalyzing an extended Michael addition reaction to form the six-membered ring in the antifungal HSAF. Biochemistry 58: 5245−5248. pdf
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| 106 | Wang Y, Tian T, Zhang J, Jin X, Yue H, Zhang XH, Du L, and Bai F. 2019. Indole reverses intrinsic antibiotic resistance by activating a novel dual-function importer. mBio 10: e00676-19. pdf |
| 105 | Li X, Wang H, Li Y, and Du L. 2019. Construction of a hybrid gene cluster to reveal a coupled ring formation-hydroxylation in the biosynthesis of the antifungal HSAF and analogues from Lysobacter enzymogenes. MedChemComm 10: 907-912. pdf
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| 104 | Chen Z, Zou J, Chen B, Du L, and Wang M. 2019. Protecting books from mold damage by decreasing paper bioreceptivity to fungal attack using de-coloured cell-free supernatant of Lysobacter enzymogenes C3. Journal of Applied Microbiology 126: 1772-1784. pdf |
| 103 | Chen Y, Yu L, Liu F, and Du L. 2018. Spermidine-regulated biosynthesis of Heat-Stable Antifungal Factor (HSAF) in Lysobacter enzymogenes OH11. Frontiers in Microbiology 9: 2984. pdf  |
| 102 | Liu Y, Wang H, Song R, Chen J, Li T, Li Y, Du L, and Shen Y. 2018. Targeted discovery and combinatorial biosynthesis of polycyclic tetramate macrolactams combamides A-E. Organic Letters 20: 3504−3508. pdf |
| 101 | Li Y, Wang H, Liu Y, Jiao Y, Li S, Shen Y, and Du L. 2018. Biosynthesis of the polycyclic system in the antifungal HSAF and analogues from Lysobacter enzymogenes. Angewandte Chemie International Edition 57: 6221-6225. pdf |
| 100 | Jiang J, Guiza-Beltran D, Schacht A, Wright S, Zhang L, and Du L. 2018. Functional and structural analysis of phenazine O-methyltransferase LaPhzM from Lysobacter antibioticus OH13 and one-pot enzymatic synthesis of the antibiotic myxin. ACS Chemical Biology 13: 1003-1012. pdf  |
| 99 | Yu L, Su W, Fey P, Liu F, and Du L. 2018. Yield improvement of the anti-MRSA antibiotics WAP-8294A by CRISPR/dCas9 combined with refactoring self-protection genes in Lysobacter enzymogenes OH11. ACS Synthetic Biology 7: 258−266. pdf |
| 98 | Xu G, Shi X, Wang R, Xu H, Du L, Chou SH, Liu H, Liu Y, Qian G, and Liu F. 2018. Insights into the distinct cooperation between the transcription factor Clp and LeDSF signaling in the regulation of antifungal factors in Lysobacter enzymogenes OH11. Biological Control 120: 52-58. pdf |
| 97 | Zhang W, Zhao B, Du L, and Shen Y. 2017. Cytotoxic polyketides with an oxygen-bridged cyclooctadiene core skeleton from the mangrove endophytic fungus Phomosis sp. A818. Molecules 22, 1547. doi:10.3390/molecules22091547. (Invited for the Special Issue in Honor of Professor Thomas James Simpson on the Occasion of His 70th Birthday). pdf. |
| 96 | Li S, Wu X, L Zhang, Shen Y, and Du L. 2017. Activation of a cryptic gene cluster in Lysobacter enzymogenes revealed a module/domain portable mechanism of nonribosomal peptide synthetases in the biosynthesis of pyrrolopyrazines. Organic Letters 19: 5010−5013. pdf. |
| 95 | Zhang W, Huffman J, Li S, Shen Y, and Du L. 2017. Unusual acylation of chloramphenicol in Lysobacter enzymogenes, a biocontrol agent with intrinsic resistance to multiple antibiotics. BMC Biotechnology 17: 59. pdf |
| 94 | Han Y, Wang Y, Yu Y, Chen H, Shen Y, and Du L. 2017. Indole-induced reversion of intrinsic multi-antibiotic resistance in Lysobacter enzymogenes. Applied and Environmental Microbiology 83:e00995-17. pdf. |
| 93 | Zhao Y, Qian G, Chen Y, Du L, and Liu F. 2017. Transcriptional and antagonistic responses of biocontrol strain Lysobacter enzymogenes OH11 to the plant pathogenic oomycete Pythium aphanidermatum. Frontiers in Microbiology 8: 1025. pdf |
| 92 | Su Z, Chen H, Wang P, Tombosa S, Du L, Han Y, Shen Y, Qian G, and Liu F. 2017. 4-Hydroxybenzoic acid is a diffusible factor that connects metabolic shikimate pathway to the biosynthesis of a unique antifungal metabolite in Lysobacter enzymogenes. Molecular Microbiology 104: 163-178. pdf |
| 91 | Zawatzky K, Reibarkh M, Canfield N, Wang TC, Li S, Du L, Welch CJ. 2016. Visualizing small differences using subtractive chromatographic analysis. Journal of Chromatography A 1468: 245-249. pdf |
| 90 | Ding Y, Li Y, Li Z, Zhang J, Lu C, Wang H, Shen Y, and Du L. 2016. Alteramide B is a microtubule antagonist of inhibiting Candida albicans. Biochimica et Biophysica Acta – General Subjects 1860:2097-2106. pdf |
| 89 | Zhao Y, Qian G, Ye Y, Wright S, Chen H, Shen Y, Liu F, and Du L. 2016. Heterocyclic aromatic N-oxidation in the biosynthesis of phenazine antibiotics from Lysobacter antibioticus. Organic Letters 18: 2495-2498. pdf |
| 88 | Xu H, Chen H, Shen Y, Du L, Chou SH, Liu L, Qian G, and Liu F. 2016. Direct regulation of extracellular chitinase production by the transcription factor LeClp in Lysobacter enzymogenes OH11. Phytopathology 106: 971-977. pdf |
| 87 | Wang R, Xu H, Du L, Chou SH, Liu H, Liu Y, Liu F, and Qian G. 2016. A TonB-dependent receptor regulates antifungal HSAF biosynthesis in Lysobacter. Scientific Reports 6: 26881. pdf |
| 86 | Wang M, Zhang W, Xu W, Shen Y, and Du L. 2016. Optimization of genome shuffling for high yield production of the antitumor deacetylmycoepoxydiene in an endophytic fungus of mangrove plants. Applied Microbiology and Biotechnology 100: 7491–7498. pdf |
| 85 | Ding Y, Li Z, Li Y, Lu C, Wang H, Shen Y, and Du L. 2016. HSAF-induced antifungal effects in Candida albicans through ROS-mediated apoptosis. RSC Advances 6: 30895-30904. pdf |
| 84 | Chen H and Du L. 2016. Iterative polyketide biosynthesis by modular polyketide synthases in bacteria. Applied Microbiology and Biotechnology 100: 541-557. pdf |
| 83 | Chen H, Olson AS, Su W, Dussault PH, and Du L. 2015. Fatty acyl incorporation in the biosynthesis of WAP-8294A, a group of potent anti-MRSA cyclic lipodepsipeptides. RSC Advances 5: 105753-105759. pdf |
| 82 | Xu L, Wu P, Wright S, Du L, and Wei X. 2015. Bioactive polycyclic tetramate macrolactams from Lysobacter enzymogenes and their absolute configurations by theoretical ECD calculations. Journal of Natural Products 78: 1841-1847. pdf |
| 81 | Zhou X, Qian G, Chen Y, Du L, Liu F, and Yuen G. 2015. PilG is involved in the regulation of twitching motility and antifungal antibiotic biosynthesis in the biological control agent Lysobacter enzymogenes. Phytopathology. 105:1318-1324. pdf |
| 80 | Yang Y, Liu B, Du X, Li P, Liang B, Cheng X, Du L, Huang D, Wang L, and Wang S. 2015. Complete genome sequence and transcriptomics analyses reveal pigment biosynthesis and regulatory mechanisms in an industrial strain, Monascus purpureus YY-1. Scientific Reports 5:8331. pdf |
| 79 | Olson AS, Chen H, Du L, and Dussault PH. 2015. Synthesis of a 2,4,6,8,10-dodecapentanoic acid thioester as a substrate for biosynthesis of Heat Stable Antifungal Factor (HSAF). RSC Advances 5: 11644-11648. pdf |
| 78 | Xu G, Zhao Y, Du L, Qian G, and Liu F. 2015. Hfq regulates antibacterial antibiotic biosynthesis and extracellular lytic-enzyme production in Lysobacter enzymogenes OH11. Microbial Biotechnology 8: 499–509. pdf. |
| 77 | Han Y, Wang Y, Tombosa S, Wright S, Huffman J, Yuen G, Qian G, Liu F, Shen Y, and Du L. 2015. Identification of a small molecule signaling factor that regulates the biosynthesis of the antifungal polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes. Applied Microbiology and Biotechnology 99: 801-811. pdf |
| 76 | Wang Y, Zhao Y, Zhang J, Zhao Y, Shen Y, Su Z, Xu G, Du L, Huffman J, Venturi V, and Qian G, and Liu F. 2014. Transcriptomic analysis reveals new regulatory roles of Clp signaling in secondary-metabolite biosynthesis and surface motility in Lysobacter enzymogenes OH11. Applied Microbiology and Biotechnology 98: 9009-9020. pdf |
| 75 | Zhang J, Du L, Liu F, Xu F, Hu B, Venturi V, and Qian G. 2014. Involvement of both PKS and NRPS in antibacterial activity in Lysobacter enzymogenes OH11. FEMS Microbiology Letters 355:170-176. pdf |
| 74 | Li Y, Chen H, Ding Y, Xie Y, Wang H, Cerny RL, Shen Y, and Du L. 2014. Iterative assembly of two separate polyketide chains by the same single-module bacterial polyketide synthase in the biosynthesis of HSAF. Angewandte Chemie International Edition 53: 7524-7530. pdf |
| 73 | Qian G, Xu F, Venturi V, Du L, and Liu F. 2014. Roles of a solo LuxR in the biological control agent Lysobacter enzymogenes strain OH11. Phytopathology 104:224-231. pdf (Editor’s Pick of the March issue of Phytopathology, March 12, 2014, pdf) | |
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| 72 | Li Y, Lou L, Cerny RL, Butchko RAE, Proctor RH, Shen Y, and Du L. 2013. Tricarballylic ester formation during biosynthesis of fumonisin mycotoxins in Fusarium verticillioides. Mycology 4: 179-186. pdf | |
| 71 | Qian G, Wang Y, Liu Y, Xu F, He Y, Venturi V, Du L, Fan J, Hu B, and Liu F. 2013. Lysobacter enzymogenes uses two distinct cell-cell signaling systems for differential regulation of secondary metabolite biosynthesis and colony morphology. Applied and Environmental Microbiology 79: 6604-6616. pdf | |
| 70 | Wang Y, Qian G, Liu F, Li Y-Z, Shen Y, and Du L. 2013. Facile method for site-specific gene integration in Lysobacter enzymogenes for yield improvement of the anti-MRSA antibiotics WAP-8294A and the antifungal antibiotic HSAF. ACS Synthetic Biology 2: 670-678. pdf | |
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| 69 | Wang Y, Qian G, Li Y, Wang YS, Wang YL, Wright S, Li Y-Z, Shen Y, Liu F, and Du L. 2013. Biosynthetic mechanism for sunscreens of the biocontrol agent Lysobacter enzymogenes. PLOS One 8(6): e66633. pdf | |
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| 68 | Zhao PJ, Yang YL, Du L, Liu JK, and Zeng Y. 2013. Elucidating the biosynthetic pathway for vibralactone: A pancreatic lipase inhibitor with a fused bicyclic ß-lactone. Angewandte Chemie International Edition 52: 1-6. pdf | |
| 67 | Xie Y, Wright S, Shen Y, and Du L. 2012. Bioactive natural products from Lysobacter. Natural Product Reports 29: 1277-1287. pdf | |
| 66 | Gonzalez DJ. Xu Y, Yang Y, Esquenazi E, Liu W, Edlund A, Duong T, Du L, Molnár I, Gerwick WH, Jensen PR, Fischbach M, Liaw C, Straight P, Dixon JE, Nizet V, and Dorrestein PC. 2012. Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange capacity of microbes. Journal of Proteomics 75: 5069-5076. pdf | |
| 65 | Li Y, Huffman J, Li Yu, Du L and Shen Y. 2012. 3-Hydroxylation of the polycyclic tetramate macrolactam in the biosynthesis of antifungal HSAF fromLysobacter enzymogenes C3. MedChemComm 3: 982-986. pdf |
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| 64 | Lou L, Chen H, Cerny RL, Li Y, Shen Y, and Du L. 2012. Unusual activities of the thioesterase domain for the biosynthesis of the polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes C3. Biochemistry 51, 4-6. pdf (Highlighted on Biochemistry website, January, 2012). |
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| 63 | Xu W, Zhu H, Tan N, Tang J, Zhang Y, Cerny RL, and Du L. 2012. An in vitro system to heterophyllin B biosynthesis in the medicinal plant Pseudostellaria heterophylla. Plant Cell, Tissue and Organ Culture 108: 137-145. pdf | |
| 62 | Zhang W, Li Y, Qian G, Wang Y, Chen H, Li Y-Z, Liu F, Shen Y, and Du L. 2011. Identification and characterization of the Anti-Methicillin-ResistantStaphylococcus aureus WAP-8294A2 biosynthetic gene cluster from Lysobacter enzymogenes OH11. Antimicrobial Agents and Chemotherapy 55, 5581-5589. pdf. |
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| 61 | Xu W, Li L, Du L, and Tan N. 2011. Various mechanisms in cyclopeptide production from precursors synthesized independently of nonribosomal peptide synthetases. Acta Biochimica et Biophysica Sinica. 43: 757-762. pdf. | |
| 60 | Hage DS, Dodds ED, Du L, and Powers R. 2011. Research in bioanalytical separations and related techniques at the Department of Chemistry, University of Nebraska. Bioanalysis 3: 1065-1076. pdf. | |
| 59 | Xie Y, Zhang W, Li Y, Wang M, Cerny RL, Shen Y, and Du L. 2011. Transformation of Fusarium verticillioides with a polyketide gene cluster isolated from a fungal endophyte activates the biosynthesis of fusaric acid. Mycology 2: 24-29. pdf | |
| 58 | Du L, Che Y and Oh H (Editors) 2011. Fungal Metabolites—Structures, Activities and Biosynthesis. Mycology 2 (1). pdf | |
| 57 | Lou L, Qian G, Xie Y, Hang J, Chen H, Zaleta-Rivera K, Li Y, Shen Y, Dussault PH, Liu F, and Du L. 2011. Biosynthesis of HSAF, a tetramic acid-containing macrolactam from Lysobacter enzymogenes. Journal of the American Chemical Society 133: 643-645. pdf |
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| 56 | Fan JT, Chen YS, Xu WY, Du L, Zeng GZ, Zhang YM, Su J, Li Y, and Tan NY. 2010. Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis. Tetrahedron Letters 51: 6810-6813. pdf | |
| 55 | Huffman J, Gerber R, and Du L. 2010. Recent advancements in the biosynthetic mechanisms for polyketide-derived mycotoxins. Biopolymers, 93: 764-776. pdf | |
| 54 | Wang J, Wang X, Zhou Y, Du L, and Wang Q. 2010. Fumonisin detection and analysis of potential fumonisin-producing Fusarium spp. in asparagus (Asparagus officinalis L.) in Zhejiang Province of China. Journal of the Science of Food and Agriculture 90: 836-842. pdf | |
| 53 | Du L and Lou L. 2010. PKSs and NRPSs releasing mechanisms. Natural Product Reports 27: 255-278. pdf |
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| 52 | Du L, Tan N, Xu W, and Lou L. 2009. Plant cyclopeptides and possible biosynthetic mechanisms. Acta Botanica Yunnanica 31: 374-382. pdf | |
| 51 | Li Y, Shen, Y, Zhu X, and Du L. 2009. Introduction of the AAL-toxin polyketide synthase gene ALT1 into FUM1-disrupted Fusarium verticillioidesproduces metabolites with the fumonisin methylation pattern. Journal of Natural Products 72: 1328-1330. pdf | |
| 50 | Gerber R, Lou L, Huffman J, Zhu X, Lin T, Li Q, Arreguin I, Butchko RAE, Proctor RH, and Du L. 2009. Advances in Understanding the biosynthesis of fumonisins. Mycotoxin Prevention and Control in Agriculture (M Appell, DF Kendra, MW Trucksess, eds.), Vol 1031, Chapter 12, pp 167-182, ACS, Washington, D. C. pdf | |
| 49 | Li S, Calvo AM, Yuen G, Du L, and Harris SD. 2009. Induction of cell wall thickening by the antifungal compound HSAF disrupts fungal growth and is mediated by sphingolipid biosynthesis. Journal of Eukaryotic Microbiology 56: 182-187. pdf | |
| 48 | Gerber R, Lou L, and Du L. 2009. A PLP-dependent polyketide chain releasing mechanism in the biosynthesis of mycotoxin fumonisins in Fusarium verticillioides. Journal of the American Chemical Society 131:3148-3149. pdf Featured on JACS website, March 2009. |
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| 47 | Zhu X, Vogeler C, and Du L. 2008. Functional complementation of fumonisin biosynthesis in FUM1-disrupted Fusarium verticillioides by the AAL-toxin polyketide synthase gene ALT1 from Alternaria alternata f. sp. Lycopersici. Journal of Natural Products 71:957-960. pdf | |
| 46 | Zhu X, Huffman J, Gerber R, Lou L, Xie Y, Lin T, Jorgenson J, Maresch A, Vogeler C, Wang Q, Shen Y, and Du L. 2008. Biosynthesis and genetic engineering of polyketides. Acta Botanica Yunnanica 30: 249-278 (invited on the occasion of the 30th anniversary of the Journal) pdf | |
| 45 | Li S, Jochum CC, Yu F, Zaleta-Rivera K, Du L, Harris SD, and Yuen G. 2008. An antifungal secondary metabolite from Lysobacter enzymogenes strain C3: isolation, biological activity and potential use in plant disease control. Phytopathology 98: 695-701. pdf | |
| 44 | Du L, Zhu X, Gerber R, Huffman J, Lou L, Jorgenson J, Yu F, Zaleta-Rivera K, and Wang Q. 2008. Biosynthesis of sphinganine-analog mycotoxins. Journal of Industrial Microbiology & Biotechnology 35: 455-464. pdf |
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| 43 | Wang J, Zhou Y, Liu W, Zhu X, Du L, and Wang Q. 2008. Fumonisin level in corn-based food and feed from Linxian County: a high-risk area for esophageal cancer in China. Food Chemistry 106: 241-246. pdf | |
| 42 | Zhu X, Yu F, Li X-C, and Du L. 2007. Production of dihydroisocoumarins in Fusarium verticillioides by swapping the ketosynthase domain of the fungal iterative modular polyketide synthase Fum1p with that of lovastatin diketide synthase. Journal of the American Chemical Society 129: 36-37. pdf |
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| 41 | Yu F, Zaleta-Rivera K, Zhu X, Huffman J, Millet J, Harris SD, Yuen G, Li X, and Du L. 2007. Structure and biosynthesis of HSAF, a broad spectrum antimycotic with a novel mode of action. Antimicrobial Agents and Chemotherapy 51: 64-72. pdf Cited by Faculty of 1000 Biology. pdf | |
| 40 | Du L. Yu F, Zhu X, Zaleta-Rivera K, Bojja RS, Ding Y, Yi H, and Wang Q. 2007. Biochemical and molecular analysis of the biosynthesis of fumonisins. Polyketides: Biosynthesis, Biological Activities and Genetic Engineering (AM Rimando and SR Baerson, ed.) ACS Symposium Series 955, ACS, Washington, D. C., pp 81-96. pdf | |
| 39 | Zhu X, Yu F, Bojja RS, Zaleta-Rivera K, and Du L. 2006. Functional replacement of the ketosynthase domain of FUM1 for the biosynthesis of fummonisins, mycotoxins with a reduced polyketide chain. Journal of Industrial Microbiology & Biotechnology 33: 859-868. pdf | |
| 38 | Zaleta-Rivera K, Xu C, Yu F, Butchko RAE, Proctor RH, Lara MEH, Raza A, Dussault PH, and Du L. 2006. A bidomain nonribosomal peptide synthetase encoded by FUM14 catalyzes the formation of tricarballylic esters in the biosynthesis of fumonisins. Biochemistry 45: 2561-2569. pdf. |
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| 37 | Li S, Du L, Yuen G, and Harris SD. 2006. Distinct ceramide synthases regulate polarized growth in the filamentous fungus Aspergillus nidulans. Molecular Biology of the Cell 17: 1218-1227. Cited by Faculty of 1000 Biology. pdf | |
| 36 | Xu L and Du L. 2006. Direct detection and quantification of Alternaria alternata lycopersici toxins using high-performance liquid chromatography-evaporative light-scattering detection. Journal of Microbiological Methods 64: 398-405. pdf | |
| 35 | Wang Q, Wang J, Yu F, Zhu X, Zaleta-Rivera K, and Du L. 2006. Mycotoxin fumonisins: Health impacts and biosynthetic mechanism. Progress in Natural Science 16: 7-15. pdf | |
| 34 | Yu F, Zhu X, and Du L. 2005. Developing a genetic system for functional manipulations of FUM1, a polyketide synthase gene for the biosynthesis of fumonisins in Fusarium verticillioides. FEMS Microbiology Letters 248: 257-264. pdf | |
| 33 | Yi H, Bojja RS, Fu J, and Du L. 2005. Direct evidence for the function of FUM13 in 3-ketoreduction of mycotoxin fumonisins in Fusarium verticillioides. Journal of Agricultural and Food Chemistry 53: 5456-5460. pdf | |
| 32 | Shen B, Chen M, Cheng Y, Du L, Edwards D, George NP, Huang Y, Oh T, Sanchez C, Tang G, Wendt-Pienkowski E, and Yi F. 2005. Prerequisites for combinatorial biosynthesis: evolution of hybrid NRPS/PKS gene clusters. Ernst Schering Res Found Workshop 51: 107-126. pdf | |
| 31 | Bojja RS, Cerny R, Proctor RH, and Du L. 2004. Determining the biosynthetic sequence in the early steps of the fumonisin pathway by use of three gene-disruption mutants of Fusarium verticillioides. Journal of Agricultural and Food Chemistry 52: 2855-2860. pdf | |
| 30 | Ding Y, Bojja RS, and Du L. 2004. Fum3p, a 2-ketoglutarate dependent dioxygenase, is required for C-5 hydroxylation of fumonisins in Fusarium verticillioides. Applied and Environmental Microbiology 70: 1931-1934. pdf | |
| 29 | Du L, Chen M, Zhang Y, and Shen B. 2003. BlmIII and BlmIV nonribosomal peptide synthetase-catalyzed biosynthesis of the bleomycin bithiazole moiety involving both in cis and in trans aminoacylation. Biochemistry 42: 9731-9740. | |
| 28 | Du L, Cheng YQ, Ingenhorst G, Tang GL, Huang Y, and Shen B. 2003. Hybrid peptide-polyketide natural products: biosynthesis and prospects towards engineering novel molecules. In Genetic Engineering, Vol. 25, Setlow, JK ed, Kluwer Academic/Plenum Publishers, pp227-267. | |
| 27 | Shen B, Du L, Sanchez C, Edwards D, Chen M, and Murrell JM. 2002. Cloning and characterization of the bleomycin biosynthetic gene cluster fromStreptomyces verticillus ATCC15003. Journal of Natural Products 65: 422-431. | |
| 26 | Shen B, Du L., Sanchez C, Edwards D, Chen M, and Murrell JM. 2001. The biosynthetic gene cluster for the anticancer drug bleomycin fromStreptomyces verticillus ATCC 15003 as a model for hybrid peptide-polyketide natural product biosynthesis. Journal of Industrial Microbiology & Biotechnology 27: 378-385. | |
| 25 | Hansen CH, Du L, Naur P, Olsen CE, Axelsen KB, Hick AJ, Pickett JA, and Halkier BA. 2001. The oxime-metabolizing enzyme CYP83B1 in the glucosinolate pathway is related to the oxime-metabolizing enzyme in the cyanogenic glucoside pathway. Journal of Biological Chemistry 276: 24790-24796. | |
| 24 | Sanchez C, Du L, Edwards D, and Shen B. 2001. Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillusATCC 15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin. Chemistry & Biology 8: 725-738. | |
| 23 | Du L and Shen B. 2001. Biosynthesis of hybrid peptide-polyketide natural products. Current Opinion in Drug Discovery and Development 4: 215-228. | |
| 22 | Du L, Sanchez C, and Shen B. 2001. Hybrid peptide-polyketide natural products: biosynthesis and prospects towards engineering novel molecules. Metabolic Engineering 3: 78-95. | |
| 21 | Shen B, Du L, Sanchez C, Chen M, and Edwards DJ. 2000. Bleomycin gene cluster components and their uses, WIPO patent number WO 040704, issued on July 13, 2000. | |
| 20 | Du L, Sanchez C, Chen M, Edwards D, and Shen B. 2000. The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase. Chemistry & Biology 7: 623-642. Featured in C & E News, 2000, 78, 33. | |
| 19 | Du L, Chen M, Sanchez C, and Shen B. 2000. An oxidation domain in nonribosomal peptide synthetases probably catalyzing the formation of thiazoles in the biosynthesis of antitumor drug bleomycin. FEMS Microbiology Letters 189:171-175. | |
| 18 | Shen Y, Gan F, Du L, Hao X. 2000. Biosynthesis of polyketides. Huaxue Jinzhan, 12: 401-408. | |
| 17 | Du L and Shen B. 1999. Identification and characterization of a type-II peptidyl carrier protein (PCP) from Streptomyces verticillus ATCC 15003.Chemistry & Biology 6: 507-517 | |
| 16 | Shen B, Du L, Sanchez C, Chen M, Edwards D. 1999. Bleomycin biosynthesis in Streptomyces verticillus ATCC 15003: a model of hybrid peptide and polyketide biosynthesis. Bioorganic Chemistry 27: 155-177. | |
| 15 | Du L and Halkier BA. 1998. Biosynthesis of glucosinolates in the developing silique walls and seeds of Sinapis alba L. Phytochemistry 48: 1145-1150. | |
| 14 | Halkier BA and Du L. 1997. The biosynthesis of glucosinolates. Trends in Plant Science 2: 425-431. | |
| 13 | Du L and Halkier BA. 1997. Involvement of cytochrome P450 in oxime production in glucosinolate biosynthesis. in Sulphur Metabolism in Higher Plants. Molecular, Ecophysiological, and Nutritional Aspects (eds. Cram, WJ, et al.). Backhuys Publishers, Leiden. The Netherlands, pp. 271-274. | |
| 12 | Du L and Halkier BA. 1996. Isolation of a microsomal enzyme system involved in glucosinolate biosynthesis from seedlings of Tropaeolum majus L. Plant Physiology 111: 831-837. | |
| 11 | Du L, Lykkesfeldt J, Olsen C, Halkier BA. 1995. Involvement of cytochrome P450 in oxime production in glucosinolate biosynthesis as demonstrated by an in vitro microsomal enzyme system isolated from jasmonic acid-induced seedlings of Sinapis abla L. Proc Natl Acad Sci USA 92: 12505-12509. | |
| 10 | Du L, Bokanga M, Møller BL, Halkier BA. 1995. The biosynthesis of cyanogenic glucosides in roots of cassava. Phytochemistry 39: 323-327. |
| 9 | Wang Z and Du L. 1995. Fast purification of coagulogen from commercial limulus reagents. Academic Journal of Kunming Medical College 16: 18-21. | |
| 8 | Koch B, Sibbesen O, Swain E, Kahn R, Du L, Bak S, Halkier B, and Møller B. 1994. Possible use of a biotechnological approach to optimize and regulate the content and distribution of cyanogenic glucosides in cassava to increase food safety. Acta Horticultura 375: 45-60. | |
| 7 | Du L, Møller B, and Halkier B. 1994. The biosynthesis of cyanogenic glucosides in tubers of Cassava (Manihot esculenta Crantz)[linamarin]. Physiologia Plantarum (Denmark). | |
| 6 | Du L and Li Y. 1993. Isolation and characterization of an antifungal protein from inflorescences of Trachycarpus fortunei W. Acta Phytophysiologica Sinica 19: 167-171. |
| 5 | Du L, Li Y, and H Y. 1993. Chitinase and ß-1,3-glucanase activities in tobacco transformed with TMV coat protein gene. Acta Botanica Yunnanica 15: 107-109. | |
| 4 | Du L, Wang S, Li Y, Hu Y, and Hu Z. 1992. Isolation and characterization of an antifungal glycoprotein from Panax japonicus var. major. Acta Botanica Yunnanica 14: 430-436. | |
| 3 | Du L, Hu Y, Li Y, Gan F, and Ji B. 1992. Isolation and characterization of an antifungal protein from Paris polyphylla var. yunnanesis F. in The Proceedings of the first Academic Annual Meeting of Young Scientists, Yunnan Association for Science and Technology, Yunnan Science and Technology Press, Kunming, pp. 225-230. | |
| 2 | Du L and Wang J. 1992. Chitinase and ß-1,3-glucanase in rice against blast disease. Acta Phytophysiologica Sinica 18: 29-36. |
| 1 | Du L and Wang J. 1990. The role of pathogenesis-related proteins in plant resistance to pathogen infection. Plant Physiology Communications 4: 1-6. | |