Welcome to the homepage for Hage Research Group at the University of Nebraska-Lincoln. Our work deals with the study and creation of new separation and analysis techniques for a broad range of  compounds, such as those that occur in biological and environmental samples. Our group is particularly interested in the use of specific binding agents like the antibodies, transport proteins, enzymes, and DNA or RNA in chemical separation. We use these binding agents in various separation methods, including high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE). This gives rise to methods referred to as high-performance affinity chromatography (HPAC) and affinity capillary electrophoresis (ACE).

There are several areas in which we are currently developing and using HPAC and affinity-based methods.  These areas, which are described in more detail under “Research”, are listed below.

Studies of Biological Interactions & Personalized Medicine by HPAC

Chromatographic-Based Immunoassays

Affinity Microcolumns

Affinity Mass Spectometry

Affinity Monolith Chromatography

Immobilization of Biomolecules

Characterization of Immobilized Biomolecules


Group News

Meet Jenna, Erynn and Stacey (from left to right). Our 2017 Summer REU students

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Review by Prof. Hage Feature on Cover of Clinical Chemistry


Prof. Hage was awarded the Outstanding Achievements in Separation Science Award at 2015 Eastern Analytical Symposium and Exposition (EAS)

David Hage with Oscar Liu

Ryan Matsuda has been featured in recruitment video for UNL’s Graduate Studies Program.