Welcome to the homepage for Hage Research Group at the University of Nebraska-Lincoln. Our work deals with the study and creation of new separation and analysis techniques for a broad range of  compounds, such as those that occur in biological and environmental samples. Our group is particularly interested in the use of specific binding agents like the antibodies, transport proteins, enzymes, and DNA or RNA in chemical separation. We use these binding agents in various separation methods, including high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE). This gives rise to methods referred to as high-performance affinity chromatography (HPAC) and affinity capillary electrophoresis (ACE).


There are several areas in which we are currently developing and using HPAC and affinity-based methods.  These areas, which are described in more detail under “Research”, are listed below.

Studies of Biological Interactions & Personalized Medicine by HPAC

Chromatographic-Based Immunoassays

Affinity Microcolumns

Affinity Mass Spectometry

Affinity Monolith Chromatography

Immobilization of Biomolecules

Characterization of Immobilized Biomolecules


Group News

Hage Group Picture-Summer 2020

Congratulations to Dr. Hage for completing 30 years at the Chemistry Department of UNL

Our 2019 REU Student Marawan Elzoeiry with Dr. David Hage and his mentors Ashley Woolfork and Kyungah Suh

Dr. Hage’s group identifies the potential cause of low testosterone