Welcome to the homepage for Hage Research Group at the University of Nebraska-Lincoln. Our work deals with the study and creation of new separation and analysis techniques for a broad range of  compounds, such as those that occur in biological and environmental samples. Our group is particularly interested in the use of specific binding agents like the antibodies, transport proteins, enzymes, and DNA or RNA in chemical separation. We use these binding agents in various separation methods, including high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE). This gives rise to methods referred to as high-performance affinity chromatography (HPAC) and affinity capillary electrophoresis (ACE).


There are several areas in which we are currently developing and using HPAC and affinity-based methods.  These areas, which are described in more detail under “Research”, are listed below.

Studies of Biological Interactions & Personalized Medicine by HPAC

Chromatographic-Based Immunoassays

Affinity Mass Spectrometry 

Affinity Monolith Chromatography

Immobilization of Biomolecules

Characterization of Immobilized Biomolecules

Group News

Congratulations to Dr. Hage for receiving the 2023 IFCC Award for Distinguished Contributions in Education from the International Federations of Clinical Chemistry (IFCC) and Laboratory Medicine in May in Rome. (Second picture: Dr.David Hage with his son Dr. Ben Hage in Rome)














Congratulations to Dr. Hage for receiving the Lila Sands Legacy Award at the 2023 UNL Chemistry Alumni Reunion Banque for celebrating the “Centennial of the First Woman to Earn a Ph.D. in Chemistry at the University of Nebraska.”


Arden Hatch, our Summer 2022 REU student presented her research poster “Determining Pharmaceutical Binding by High-Performance Affinity Chromatography” at the 2022 REU Research Symposium at UNL. Here is a picture of Arden with her mentors -Sadia Sharmeen and Isaac Kyei and advisor, Dr. David Hage.


Congratulations to Dr. Hage for receiving the 2022 AACC Merit Award for “Outstanding Contributions to Education in Clinical Chemistry”! Read the full news in the link given below!



Congratulations to Dr. Hage for winning the 2021 ACS Award in Chromatography!



Congratulations to Dr. Hage for receiving the 2021 Certificate of Appreciation for Teaching or Assistance to Students from UNL Parent Organization!