Publications

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** Undergraduate or high school author


2020

82. Layer-by-Layer Assembly of a [Fe-(pyrazine){Pd(CN)4}] Spin Crossover Thin Film. McElveen, K. A., Hao, G., Evans, P. E., Ekanayaka, T. K., N’Diaye, A. T., Lai, R. Y.* (under review)

81. Laser Vibrational Excitation of Radicals to Prevent Crystallinity Degradation Caused by Boron Doping in Diamonds. Fan, L., Constantin, L., Wu, Z., McElveen, K. A., Chen, X., He, T., Wang, F., Cui, B, Lai, R. Y., Li, X., Silvain, J.-F., g Lu, Y.-F.* (under revision)

80. The Role of Amine in the Sequestration of As(III) on Functionalized Indium Tin Oxide, Evans, P. E., Yost, A. J.,  McElveen, K. A.,  Shi, Q.-Y., Ekanayaka,T. K., Manna,A. K., Schlegel, V.,  Dowben, P. A., Lai, R. Y., Varma, S.* Applied Surface Science 2020 (in press)

79. Engineering Uranyl-chelating Peptides from NikR for Electrochemical Peptide-based Sensing Applications, Stellato, C. C., Lai, R. Y.* Journal of Electroanalytical Chemistry 2020, 858, 113698.

78. Waste to Wealth Translation of E-waste to Plasmonic Nanostructures for Surface Enhanced Raman Scattering. Devi, P.*, Hipp, K., Thakur, A., Lai, R. Y.* Applied Nanoscience 2020, 10, 1615-1623.


2019

77. Electrochemical Aptamer-based Sensors for Food and Water Analysis: A Review. Li, F., Yu, Z.*, Han, X., Lai, R. Y.* Anal. Chim. Acta 2019, 1051, 1-23.

Lai ACA Graphical Absract 090318

76. Progress in the Materials for Optical Detection of Arsenic in Water. Devi, P.*, Thakur, A., Lai, R. Y.*, Saini, S., Jain, R., Kumar, P.* TrAC Trends in Analytical Chemistry 2019, 110, 97-115.

TrAC Review TOC 100818


2018

75. Effects of Redox Label Location on the Performance of an Electrochemical Aptamer-based Tumor Necrosis Factor Alpha Sensor. Mayer, M. D., Lai, R. Y.* Talanta 2018, 189, 585-591.

Miles TNFa

74. Application of Calcium-binding Motif of E-cadherin for Electrochemical Detection of Pb(II). Lofti Zadeh Zhad, H. R.; Lai, R. Y.* Anal. Chem. 2018, 90, 6519-6525.

Hamid Pb Sensor

73. Towards the Development of a Sensitive and Selective Electrochemical Aptamer-based Ampicillin Sensor. Yu, Z.; Sulief, A. L.; Lai, R. Y.* Sensors and Actuators B: Chemical 2018, 258, 722-729.

SAB TOC Andy

72. A Reagentless and Reusable Electrochemical Aptamer-based Sensor for Rapid Detection of Ampicillin in Complex Samples. Yu, Z.; Lai, R. Y.* Talanta 2018, 176, 619-624.

Andy AMP Talanta website pic


2017

71. Hexavalent Chromium as an Electrocatalyst in DNA Sensing. Lofti Zadeh Zhad, H. R.; Lai, R. Y.* Anal. Chem. 2017, 89, 13342-13348.

Website TOC

70. A Reagentless and Reusable Electrochemical Aptamer-based Sensor for Rapid Detection of Cd(II). Lofti Zadeh Zhad, H. R.; Rodriquez Torres, Y. M.**; Lai, R. Y.* Journal of Electroanalytical Chemistry 2017, 803, 89-94.

Website JELECHEM Cd paper

69. A Tunable “Signal-off” and “Signal-on” Electrochemical Cisplatin Sensor. Wu, Y.; Lai, R. Y.* Anal. Chem. 2017, 89, 9984-9989.

Picture1

68. Iron(III)-mediated Electrochemical Detection of Levofloxacin in Complex Biological Samples. Lofti Zadeh Zhad, H. R.; Lai, R. Y.* Electroanalysis 2017, 29, 2672-2677.

Pic on website Levo

67. Effects of DNA Probe Length on the Performance of a Dynamics-based Electrochemical Hg(II) Sensor. Wu, Y.; Baker, S. L.**; Lai, R. Y.* Electroanalysis 2017, 29, 2239-2245.

Lai Lab website paper pic

66. Electrochemiluminescence Detection in Paper-based and Other Inexpensive Microfluidic Devices. Gross, E. M.*; Durant H. E.**; Hipp, K. N.; Lai, R. Y.* ChemElectroChem 2017, 4, 1594–1603.

ECL 1

65. Structural and Optical Properties of Alumina Passivated Amorphous Si Slanted Columnar Thin Films During Electrochemical Li-ion Intercalation and Deintercalation Observed by In-situ Generalized Spectroscopic Ellipsometry. Sekora, D.; Lai, R. Y.; Schmidt, D.; Schubert, M.; Schubert, E.* Journal of Vacuum Science & Technology B 2017, 35, 031401. (Editor’s Pick)

Li SCTF

64. Chapter 8 – Folding- and Dynamics-based Electrochemical DNA Sensors. Lai, R. Y. Enzymes as Sensors, Methods in Enzymology 2017, 589, 221-252.

TOC


2016

63. Solution-stable Anisotropic Carbon Nanotube/graphene Hybrids Based on Slanted Columnar Thin Films for Chemical Sensing. Wilson, P. M.; Zobel, A.**; Zaitouna, A. J.; Lipatov, A.; Schubert, E.; Hofmann, T.; Schubert, M.; Lai, R.; Sinitskii, A.* RSC Adv. 2016, 6, 63235-63240.

 GA

62. A Reagentless DNA-based Electrochemical Silver(I) Sensor for Real Time Detection of Ag(I) — the Effect of Probe Sequence and Orientation on Sensor Response. Wu, Y.; Lai, R. Y.* Biotechnology Journal 2016, 11, 788-796.

Ag_TOC

61. An Electrochemical Gold(III) Sensor with High Sensitivity and Tunable Dynamic Range. Wu, Y.; Lai, R. Y.* Anal. Chem. 2016, 88, 2227-2233.
Au_AC_TOC


2015

60. Electrochemical Detection of Platinum (IV) Prodrug Satraplatin in Serum. Wu, Y.; Lai, R. Y.* Anal. Chem. 2015, 87, 11092-11097.

Picture1

59. Scanning Electrochemical and Fluorescence Microscopy for Detection of Reactive Oxygen Species in Living Cells. Salamifar, S. E.; Lai, R. Y.* ACS Symposium Series eBooks. Oxidative Stress: Diagnostics, Prevention, and Therapy Volume 2, 2015, Chapter 17, 415-430.

Picture1

58. Comparison of Nanostructured Silver-modified Silver and Carbon Ultramicroelectrodes for Electrochemical Detection of Nitrate. Lofti Zadeh Zhad, H. R.; Lai, R. Y.* Anal. Chim. Acta 2015, 892, 153-159.

Picture1

57. Incorporation of Extra Amino Acids in Peptide Recognition Probe to Improve Specificity and Selectivity of an Electrochemical Peptide-based Sensor. Zaitouna, A. J.; Maben, A. J.**; Lai, R. Y.* Anal. Chim. Acta 2015, 886, 157-164.

TOC

56. Comparison of Mannose, Ethylene Glycol and Methoxy-terminated Diluents on Specificity and Selectivity of Electrochemical Peptide-based Sensors. Zaitouna, A. J.; Joyce, J.**; Cerny, R. L.; Dussault, P. H.; Lai, R. Y.*  Anal. Chem. 2015, 87, 6966-6973.

EG_MEG_TOC 

55. Methylene Blue-Mediated Electrocatalytic Detection of Hexavalent Chromium. Korshoj, L. E.**; Zaitouna, A. J.; Lai, R. Y.* Anal. Chem. 2015, 87, 2560-2564.

TOC_pic


2014

54. Electrochemical Hydrogen Peroxide Sensors Fabricated Using Cytochrome c Immobilized on Macroelectrodes and Ultramicroelectrodes. Salamifar, S. E.; Lee, S.**; Lai, R. Y.* Colloids and Surfaces B: Biointerfaces 2014, 123, 866-869.

CytC_Ehsan 

53. Effects of DNA Probe and Target Flexibility on the Performance of a “Signal-on” Electrochemical DNA Sensor. Wu, Y.; Lai, R. Y.* Anal. Chem. 2014, 86, 8888-8895.

Yao_AT_Anal_Chem_TOC

52. Application of Electrochemical Surface Plasmon Resonance Spectroscopy for Characterization of Electrochemical DNA Sensors. Salamifar, S. E.; Lai, R. Y.*Colloids and Surfaces B: Biointerfaces 2014, 122, 835-839.

ESPR_Ehsan

51. Hg(II)-mediated “Signal-on” Electrochemical Glutathione Sensor. Lofti Zadeh Zhad, H. R.; Lai, R. Y.* Chem. Commun. 2014, 50, 8385- 8387.

GSH_Hamid_TOC 

50. An Electrochemical Peptide-based Ara h 2 Antibody Sensor Fabricated on a Nickel (II)-Nitriloacetic Acid Self-assembled Monolayer Using a His-tagged Peptide. Zaitouna, A. J.; Lai, R. Y.* Anal. Chim. Acta 2014, 828, 85-91.

Arah2-Anita_TOC

49. Use of Thiolated Oligonucleotides as Anti-fouling Diluents in Electrochemical Peptide-based Sensors. McQuistan, A.**; Zaitouna, A. J.; Echeverria, E.; Lai, R. Y.* Chem. Commun. 2014, 50, 4690-4692.

Adam_DRY_T246_TOC

48. Fabrication of Electrochemical DNA Sensors on Gold-modified Recessed Platinum Nanoelectrodes. Salamifar, S. E.; Lai, R. Y.* Anal. Chem. 2014, 86, 2849-2852.

Ehsan_Nanoelectrode_TOC

47. Effect of Redox Label Tether Length and Flexibility on Sensor Performance of Displacement-based Electrochemical Nucleic Acid Sensors. Yu, Z.; Zaitouna, A. J.; Lai, R. Y.* Anal. Chim. Acta 2014, 812, 176-183.

Andy_T3_T5_ACA_TOC

46. Three-Dimensional Periodic Graphene Nanostructures. Wilson, P.; Mbah, G. N.; Smith, T. G.; Schmidt, D.; Lai, R. Y.; Hofmann, T.; Sinitskii, A.* J. Mater. Chem. C 2014, 2, 1879-1886.

Graphene_JMC_Sinitskii_TOC

45. Characterization of an Electrochemical Mercury Sensor Using Alternating Current, Cyclic, Square Wave and Differential Pulse Voltammetry. Guerreiro, G. V.**; Zaitouna, A. J.; Lai, R. Y.* Anal. Chim. Acta 2014, 810, 79-85.

Gabriela_Hg_TOC


2013

44. Use of Combined Scanning Electrochemical and Fluorescence Microscopy for Detection of Reactive Oxygen Species in Prostate Cancer Cells. Salamifar, S. E.; Lai, R. Y.* Anal. Chem. 2013, 85, 9417-9421.

43. Electrochemical Techniques for Characterization of Stem-loop Probe and Linear Probe-based DNA Sensors. Lai, R. Y.*; Walker, B.**; Stormberg, K.**; Zaitouna, A. J.; Yang, W. Methods 2013, 64, 267-275.

42. A Whole-cell Sensor for the Detection of Gold. Zammit, C. M.*; Quaranta, D.; Gibson, S.; Zaitouna, A. J.; Ta, C.; Brugger, J.; Lai, R. Y.; Grass, G.; Reith, F. PLoS ONE 8(8): e69292.

41. Design and Synthesis of a New Class of Twin-Chain Amphiphiles for Self-Assembled Monolayer-based Electrochemical Biosensor Applications. Fisher, T. J.; Cañete, S. J. P.; Lai, R. Y.; Dussault, P. H.* European Journal of Organic Chemistry 2013, 16, 3263-3270.

40. Development of a “Signal-on” Electrochemical DNA Sensor with an Oligo-thymine Spacer for Point Mutation Detection. Wu, Y.; Lai, R. Y.* Chem. Commun. 2013, 49, 3422-3424.

39. The Effect of Signaling Probe Conformation on Sensor Performance of a Displacement-based Electrochemical DNA Sensor. Yu, Z.; Lai, R. Y.* Anal. Chem. 2013, 85, 3340-3346.

38. Conference Report: Chemistry: A Bridge to Discovery. Gross, E. M.*; Lai, R. Y., Bioanalysis 2013, 5, 131-133.

37. Development of an Electrochemical Insulin Sensor Based on the Insulin-linked Polymorphic Region. Gerasimov, J. Y.; Schaefer, C. S.; Yang, W.; Grout, R. L.**; Lai, R. Y.* Biosens. Bioelectron. 2013, 42, 62-68.


2012

36. A Reagentless and Reusable Electrochemical DNA Sensor Based on Target Hybridization-induced Stem-loop Probe Formation. Yu, Z.; Lai, R. Y.* Chem. Commun. 2012, 48, 10523-10525.

35. A Dual-signalling Electrochemical DNA Sensor Based on Target Hybridization-induced Change in DNA Probe Flexibility. Yang, W.; Lai, R. Y.* Chem. Commun. 2012, 48, 8703-8705.


2011

34. Combined Optical and Acoustical Method for Determination of Thickness and Porosity of Transparent Organic Layers Below the Ultra-thin Film Limit. Rodenhausen, K. B.*; Kasputis, T.; Pannier, A. K.; Gerasimov, J. Y.; Lai, R. Y.; Solinsky, M.; Tiwald, T. E.; Wang, H.; Sarkar, A.; Hofmann, T.; Ianno, N.; Schubert, M. Rev. Sci. Instrum. 2011, 82, 103111-103120.

33. Comparison of the Stem-loop and Linear Probe-based Electrochemical DNA Sensors by Alternating Current Voltammetry and Cyclic Voltammetry. Yang, W.; Lai, R. Y.* Langmuir 2011, 27, 14669-14677.

32. Design and Characterization of a Metal Ion-Imidazole Self-Assembled Monolayer for Reversible Immobilization of Histidine-tagged Peptides. Zaitouna, A. J.; Lai, R. Y.* Chem. Commun. 2011, 47, 12391-12393.

31. Application of Synchrotron FTIR Microspectroscopy for Determination of Spatial Distribution of Methylene Blue Conjugated onto a SAM via “Click” Chemistry. Cañete, S. J. P.; Zhang, Z.; Kong, L.; Schlegel, V. L.; Plantz, B. A.; Dowben, P. A.; Lai, R. Y.* Chem. Commun. 2011, 47, 11918-11920.

30. Integration of Two Different Sensing Modes in an Electrochemical DNA Sensor for Approximation of Target Mismatch Location. Yang, W.; Lai, R. Y.* Electrochemistry Communications 2011, 13, 989-992.

29. Design and Characterization of an Electrochemical Peptide-based Sensor Fabricated via “Click” Chemistry.  Gerasimov, J. Y.; Lai, R. Y.* Chem. Commun. 2011, 47, 8688-8690.

28. High-sensitivity Detector for Molecular Sensing Using Magnetic Particles. Le Roy, D.*; Yang, W.; Yin, X.; Lai, R. Y.; Liou, S.-H.; Sellmyer, D. J. Journal of Applied Physics 2011, 109, 07E532.

27. A Folding-based Electrochemical Aptasensor for Detection of Vascular Endothelial Growth Factor in Human Whole Blood. Zhao, S.; Yang, W.; Lai, R. Y.* Biosensors and Bioelectronics 2011, 26, 2442-2447.

26. Effect of Diluent Chain Length on the Performance of the Electrochemical DNA Sensor at Elevated Temperature. Yang, W.; Lai, R. Y.* Analyst 2011, 136, 134-139.


2010

25. Fabrication of an Electrochemical DNA Sensor Array via Potential-assisted “Click” Chemistry. Caňete, S. J. P.; Lai, R. Y.* Chem. Commun. 2010, 46, 3941-3943.

24. An Electrochemical Peptide-based Biosensing Platform for HIV Detection. Gerasimov J. Y.; Lai, R. Y.* Chem. Commun. 2010, 46, 395-397.


2009

23. Folding-based Electrochemical DNA Sensor Fabricated by “Click” Chemistry . Caňete, S. J. P.; Yang, W.; Lai, R. Y.* Chem. Commun. 2009, 4835-4837.

22. Folding-based Electrochemical DNA Sensor Fabricated on a Gold-plated Screen-printed Carbon Electrode. Yang, W.; Gerasimov J. Y.; Lai, R. Y.* Chem. Commun. 2009, 20, 2902-2904.

21. Continuous, Real-Time Monitoring of Cocaine in Undiluted Blood Serum via a Microfluidic, Electrochemical Aptamer-Based Sensor. Swensen, J. S.; Xiao, Y.; Ferguson, B. S.; Lubin, A. A.; Lai, R. Y.; Heeger, A. J.; Plaxco, K. W.; Soh, H. T.* J. Am. Chem. Soc. 2009, 131, 4262-4266.


2008

20. Microfluidic Device Architecture for Electrochemical Patterning and Detection of Multiple DNA Sequences. Pavlovic, E.; Lai, R. Y.; Wu, T. T.; Ferguson, B. S.; Sun, R.; Plaxco, K. W.; Soh, H. T.* Langmuir 2008, 24, 1102-1107.


2007

19. Preparation of Electrode-immobilized, Redox-modified Oligonucleotides for Electrochemical DNA and Aptamer-based Sensing. Xiao, Y.; Lai, R. Y.; Plaxco, K. W.* Nature Protocols 2007, 2, 2875-2880.

18. Linear, Redox Modified DNA Probes as Electrochemical DNA Sensors. Ricci, F.; Lai, R. Y.; Plaxco, K. W.* Chem. Commun. 2007, 36, 3768-3770.

17. Effect of Molecular Crowding on the Response of an Electrochemical DNA Sensor. Ricci, F.; Lai, R. Y.; Heeger, A. J.; Plaxco, K. W.; Sumner, J. J.* Langmuir 2007, 23, 6827-6834.

16. Aptamer-Based Electrochemical Detection of Picomolar Platelet-Derived Growth Factor Directly in Blood Serum. Lai, R. Y.; Plaxco, K. W.*; Heeger, A. J. Anal. Chem. 2007, 79, 229-233.


2006

15. A Comparison of the Signaling and Stability of Electrochemical DNA Sensors Fabricated from 6- or 11-Carbon Self-Assembled Monolayers. Lai, R. Y.; Seferos, D. S.; Heeger, A. J.; Bazan, G. C.; Plaxco, K. W.* Langmuir 2006, 22, 10796-10800.

14. α, ω-Dithiol Oligo(phenylenevinylene)s for the Preparation of High-Quality π-Conjugated SAMs and Nanoparticle Functionalized Electrode. Seferos, D. S.; Lai, R. Y.; Plaxco, K. P.; Bazan, G. C.* Adv. Func. Mater. 2006, 16, 2387-2392.

13. Sequence-Specific, Electronic Detection of Oligonucleotides in Blood, Soil and Foodstuffs with the Reagentless, Reusable E-DNA Sensor. Lubin, A. A.; Lai, R. Y.; Baker, B. R.; Heeger, A. J.; Plaxco, K. W.* Anal. Chem. 2006, 78, 5671-5677.

12. An Electronic Aptamer-Based Small Molecule Sensor for the Rapid, Label-Free Detection of Cocaine in Adulterated Samples and Biological Fluids. Baker, B. R.; Lai, R. Y.; Wood, M. S.**; Doctor, E. H.**; Heeger, A. J.; Plaxco, K. W.* J. Am. Chem. Soc. 2006, 128, 3138-3139.

11. Rapid, Sequence-Specific Detection of Unpurified PCR Amplicons Via a Reusable, Electronic Sensor. Lai, R. Y.; Legally, E. T.; Lee, S-H.; Soh, H. T.; Plaxco, K. W.*; Heeger, A. J.* Proc. Natl. Acad. Sci. 2006, 103, 4017-4021.

10. Differential Labeling of Closely-spaced Biosensor Electrodes via Oxidative Desorption. Lai, R. Y.; Lee, S-H.; Soh, H. T.; Plaxco, K. W.*; Heeger, A. J. Langmuir 2006, 22, 1932-1936.


2004

9. Electrons Are Transported through Phenylene-Ethynylene Oligomer Monolayers via Localized Molecular Orbitals. Fan, F-R. F.; Lai, R. Y.; Cornil, J.; Karzazi, Y.; Brédas, J-L.; Cai, L.; Cheng, L.; Yao, Y.; Price, D. W.; Dirk, S. M.; Tour, J. M.; Bard, A. J.* J. Am. Chem. Soc. 2004, 126, 2568-2573.

8. Photophysical, Electrochemical, and Electrogenerated Chemiluminescent Studies of Selected Nonplanar Pyrenophanes. Lai, R. Y.; Fleming, J. J.; Merner, B. L.; Vermeij, R. J.; Bodwell, G. J.; Bard, A. J.* J. Phys. Chem. A 2004, 108, 376-383.


2003

7. Synthesis, Cyclic Voltammetric Studies, and Electrogenerated Chemiluminescence of a New Phenoquinoline-Biphenothiazine Donor-Acceptor Molecule. Lai, R. Y.; Kong, X.; Jenekhe, S. A.; Bard, A. J.* J. Am. Chem. Soc. 2003, 125, 12631-12639.

6. Photophysical, Electrochemical and Electrogenerated Chemiluminescent Properties of Selected Dipyrromethene-BF2 Dyes. Lai, R. Y.; Bard, A. J.* J. Phys. Chem. B 2003, 107, 5036-5042.

5. The Application of ECL to Determine Electrode Potentials of Tri-n-propylamine, its Radical Cation, and Intermediate Free Radical in MeCN/Benzene Solutions. Lai, R. Y.; Bard, A. J.* J. Phys. Chem. A 2003, 107, 3335-3340.


2002

4. Detection of Sodium Ion with a Ruthenium (II) Complex With Crown-Ether Moiety at 3, 3’-Positions on the 2, 2’-Bipyridine Ligand. Lai, R. Y.; Chiba, M,; Kitamura, N.; Bard, A. J.* Anal. Chem. 2002, 74, 551-553.


2001

3. Synthesis, Cyclic Voltammetric Studies and Electrogenerated Chemiluminescence of a New Donor-Acceptor Molecule: 3,7-[bis[4-phenyl-2-quinolyl]]-10-methylphenothiazine. Lai, R. Y.; Fabrizio, E. F.; Lu, L.; Jenekhe, S. A.; Bard, A. J.* J. Am. Chem. Soc. 2001, 123, 9112-9118.

2. Quantification of Dopant Ions in Polypyrrole Films with Electrochemical ICP-Atomic Emission Spectrometry: Development and Comparison with Electrochemical Quartz Crystal Microbalance Studies. Briseno, A. L.; Baca, A. J.**; Zhou, Q.; Lai, R. Y.**; Zhou, F.* Anal. Chim. Acta 2001, 441, 121-132.


1998

1. Selective Determination of Methylmercury by Flow-Injection Fast-Scan Voltammetry. Lai, R. Y.**; Huang, E. L.; Zhou, F.*; Wipf, D. O. Electroanalysis 1998, 10, 926-930.


Patents

5. Electrochemical Sensors and Methods of Using

Lai, R. Y. (Application number: 20150177181)

http://nutech.flintbox.com/public/project/28363/

4. Combined Use of Oscillating Means and Ellipsometry to Determine Uncorrelated Effective Thickness and Optical Constants of Material Deposited at or Etched from a Working Electrode that Preferably Comprises Non-normal Oriented Nanofibers

Schubert, M. M.; Hofmann, T.; Woolam, J. A.; Lai, R. Y. (US Patent Number: 10,048,059; Issued: Aug 14, 2018).

3. Self-assembled Monolayers and Methods for Using the Same in Biosensing Applications

Dussualt, P. H.; Lai, R. Y.; Fisher, T.; Zaitouna, A. J. (US Patent Number: 9,829,487; Issued: Nov 28, 2017)

http://nutech.flintbox.com/public/project/28613/

2. Optical Sensing and Separation Based on Ordered Three-dimensional Nanostructured Surfaces

Schubert, M. M.; Hofmann, T.; Schmidt, D.; Dussault, P. H.; Holmes, A.; Lai, R. Y. (US Patent Number: 10,190,978; Issued: Jan 29, 2019)

1. Optical Sensing and Separation Based on Ordered Three-dimensional Nanostructured Surfaces

Schubert, M. M.; Hofmann, T.; Schmidt, D.; Dussault, P. H.; Holmes, A.; Lai, R. Y. (US Patent Number: 9,739,710; Issued: Aug 22, 2017)