Our research seeks to discover new methods to control (e.g., synthesize, assemble, manipulate, organize, etc.) hard materials with soft materials. These “soft” fabrication tools will enable new hybrid structures—those that combine hard inorganic and soft organic components—with dynamic properties (chemical, physical, and structural) that are useful to applications such as soft sensing and electronics. In these efforts, we emphasize systems with heterogeneous chemical, structural, and physical attributes that can be reversibly reconfigured using simple, macro-scale processes such as mechanical deformation. The micro-scale features (e.g., surface chemistry or structure) of these materials are readily organized and manipulated on length scales commensurate with their size, even when large numbers of objects are involved. Active projects include: (i) Mechano-chemical Surfaces, and (ii) Soft, Stretchable Reactors.