{"id":133,"date":"2014-02-20T13:12:25","date_gmt":"2014-02-20T19:12:25","guid":{"rendered":"http:\/\/chemweb.unl.edu\/ldu\/?page_id=133"},"modified":"2025-07-01T14:36:10","modified_gmt":"2025-07-01T19:36:10","slug":"recent-publications","status":"publish","type":"page","link":"http:\/\/chemweb.unl.edu\/ldu\/recent-publications\/","title":{"rendered":"Recent Publications"},"content":{"rendered":"

For a complete list of publications, click here<\/a><\/h3>\n

For citations and h-index, click here<\/a>
\n<\/a><\/h3>\n

 <\/p>\n

Selected Recent Publications<\/strong><\/h4>\n

 <\/p>\n

Xie X, Li F, Mu Y, Lu M, Luo J, Wang H, Shen Y, Du L<\/strong>, Zhu D, and Li Y. 2025<\/strong>. Structural basis for medium-chain dehydrogenase\/reductase-catalyzed reductive cyclization in polycyclic tetramate macrolactam biosynthesis. Journal of American Chemical Society<\/em><\/strong> 147: 19153-19261. pdf<\/a><\/p>\n

Li X, Pan C, Wang H, Shen Y, Li Y, and Du L. 2025<\/strong>. Heterologous production of phenazines in the biocontrol agent Lysobacter enzymogenes<\/em> C3. Journal of Agricultural and Food Chemistry<\/strong><\/em> 73: 1345-1355. pdf<\/a><\/p>\n

Zhang F, Liu J, Jiang L, Zheng Y, Yu L, and Du L.<\/strong> 2024<\/strong>. Production of the siderophore lysochelin in rich media through maltose-promoted high-density growth of Lysobacter<\/em> sp. 3655. Frontiers in Microbiology <\/em><\/strong>15:1433983. pdf<\/a><\/p>\n

Miller A, Li S, Eichhorn CD, Zheng Y, and Du L.<\/strong> 2023<\/strong>. Identification and biosynthetic study of the siderophore lysochelin in the biocontrol Agent Lysobacter enzymogenes<\/em>. Journal of Agricultural and Food Chemistry <\/em><\/strong>71: 7418-7426. pdf<\/a><\/p>\n

Han W, Zhai Y, Zhang R, Gong X, Li J, Xu G, Lei X, Du L<\/strong>, and Gao J.<\/strong> 2023<\/strong>. Tricrilactones A\u2212H, potent antiosteoporosis macrolides with distinctive ring skeletons from Trichocladium crispatum<\/em>, an alpine moss-associated fungus. Angewandte Chemie International Edition <\/em><\/strong>62: e202300773. pdf<\/a>.<\/p>\n

Yue H, Miller A, Khetrapal V, Jayasekera V, Wright S, and Du L.<\/strong> 2022<\/strong>. Biosynthesis, regulation, and engineering of natural products from Lysobacter<\/em>. Natural Product Reports<\/em><\/strong> 39: 842 \u2013 874. pdf<\/a><\/p>\n

Yue H, Jiang J, Taylor A, Leite A, Dodds E, and Du L.<\/strong>\u00a02021<\/strong>. Outer membrane vesicles-mediated co-delivery of the antifungal HSAF metabolites and lytic polysaccharide monooxygenase in the predatory Lysobacter enzymogenes<\/em>. ACS Chemical Biology <\/em><\/strong>16: 1079-1089. pdf<\/a><\/p>\n

Yu L, Li H, Zhou Z, Liu F, and Du L.<\/strong>\u00a02021<\/strong>. An antifungal polycyclic tetramate macrolactam HSAF is a novel oxidative stress modulator in Lysobacter enzymogenes<\/em>. Applied and Environmental Microbiology<\/em><\/strong> 87: e03105-20. pdf<\/a><\/p>\n

Yu L, Du F, Chen X, Zheng Y, Morton M, Liu F, and Du L.<\/strong>\u00a02020<\/strong>. Identification of the biosynthetic gene cluster for the anti-MRSA lysocins through gene cluster activation using strong promoters of housekeeping genes and production of new analogs in Lysobacter<\/em> sp. 3655. ACS Synthetic Biology<\/em><\/strong> 9: 1989-1997. pdf<\/a><\/p>\n

Sang M, Wang H, Shen Y, Rodrigues de Almeida N, Conda-Sheridan M, Li S, Li Y, and\u00a0Du L.<\/strong>\u00a02019<\/strong>. Identification of an anti-MRSA cyclic lipodepsipeptide, WBP-29479A1, by genome mining of\u00a0Lysobacter antibioticus<\/em>.\u00a0Organic Letters<\/em><\/strong> 21: 6432-6436. pdf<\/a>.<\/p>\n

Li X, Wang H, Shen Y, Li Y, and\u00a0Du L. 2019.<\/strong>\u00a0OX4 is an NADPH-dependent dehydrogenase catalyzing an extended Michael addition reaction to form the six-membered ring in the antifungal HSAF.\u00a0Biochemistry<\/i><\/strong> 58: 5245\u22125248. pdf<\/a><\/p>\n

Li Y, Wang H, Liu Y, Jiao Y, Li S, Shen Y, and\u00a0Du L.\u00a02018.<\/strong>\u00a0Biosynthesis of the polycyclic system in the antifungal HSAF and analogues from\u00a0Lysobacter enzymogenes<\/em>.\u00a0Angewandte Chemie International Edition\u00a0<\/strong><\/em>57: 6221-6225.\u00a0pdf<\/a><\/p>\n

Jiang J, Guiza-Beltran D, Schacht A, Wright S, Zhang L, and Du L. 2018.<\/strong> Functional and structural analysis of phenazine O<\/em>-methyltransferase LaPhzM from Lysobacter antibioticus<\/em> OH13 and one-pot enzymatic synthesis of the antibiotic myxin. ACS Chemical Biology<\/strong><\/em>\u00a013: 1003-1012.\u00a0pdf<\/a>.<\/p>\n

Yu L, Su W, Fey P, Liu F, and\u00a0Du L.\u00a02018.<\/strong>\u00a0Yield improvement of the anti-MRSA antibiotics WAP-8294A by CRISPR\/dCas9 combined with refactoring self-protection genes in\u00a0Lysobacter enzymogenes<\/em>\u00a0OH11.\u00a0ACS Synthetic Biology\u00a0<\/strong><\/em>7: 258\u2212266.\u00a0pdf<\/a>.<\/p>\n

Li S, Wu X, L Zhang, Shen Y, and\u00a0Du L. 2017.\u00a0<\/strong>Activation of a cryptic gene cluster in\u00a0Lysobacter enzymogenes\u00a0<\/em>revealed a module\/domain portable mechanism of nonribosomal peptide synthetases in the biosynthesis of pyrrolopyrazines.\u00a0Organic Letters<\/em><\/strong>\u00a019: 5010\u22125013. pdf<\/a>.<\/p>\n

Han Y, Wang Y, Yu Y, Chen H, Shen Y, and\u00a0Du L. 2017.<\/strong>\u00a0Indole-induced reversion of intrinsic multi-antibiotic resistance in\u00a0Lysobacter enzymogenes<\/em>.\u00a0Applied and Environmental Microbiology<\/strong><\/em>\u00a083:e00995-17. pdf<\/a>.<\/p>\n

Zhao Y, Qian G, Ye Y, Wright S, Chen H, Shen Y, Liu F, and\u00a0Du L. 2016.<\/strong> Heterocyclic aromatic N<\/i>-oxidation in the biosynthesis of phenazine antibiotics from Lysobacter antibioticus<\/i>. Organic Letters <\/strong><\/em>18: 2495-2498.\u00a0pdf<\/a><\/p>\n

Wang M, Zhang W, Xu W, Shen Y, and\u00a0Du L. 2016.<\/strong>\u00a0Optimization of genome shuffling for high yield production of the antitumor deacetylmycoepoxydiene in an endophytic fungus of mangrove plants.\u00a0Applied Microbiology and Biotechnology<\/strong><\/em>\u00a0100: 7491\u20137498.\u00a0pdf<\/a><\/p>\n

Han Y, Wang Y, Tombosa S, Wright S, Huffman J, Yuen G, Qian G, Liu F, Shen Y, and Du L. 2015<\/strong>. Identification of a small molecule signaling factor that regulates the biosynthesis of the antifungal polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes<\/em>. Applied Microbiology and Biotechnology<\/strong><\/em><\/i>\u00a0<\/i><\/b>99: 801-811.\u00a0pdf<\/a>
\n<\/a><\/p>\n

Li Y, Chen H, Ding Y, Xie Y, Wang H, Cerny RL, Shen Y, and\u00a0Du L.\u00a02014<\/strong>. Iterative assembly of two separate polyketide chains by the same single-module bacterial polyketide synthase in the biosynthesis of HSAF.\u00a0Angewandte Chemie International Edition<\/strong><\/em>\u00a053: 7524-7530.\u00a0pdf<\/a><\/p>\n

Wang Y, Qian G, Liu F, Li Y-Z, Shen Y, and\u00a0Du L.\u00a02013<\/strong>. Facile method for site-specific gene integration in\u00a0Lysobacter enzymogenes<\/i>\u00a0for yield improvement of the anti-MRSA antibiotics WAP-8294A and the antifungal antibiotic HSAF.\u00a0ACS Synthetic Biology<\/i><\/strong>\u00a02: 670-678. pdf<\/a><\/p>\n

Zhao PJ, Yang YL,\u00a0Du L<\/strong>, Liu JK, and Zeng Y.\u00a02013<\/strong>. Elucidating the biosynthetic pathway for vibralactone: A pancreatic lipase inhibitor with a fused bicyclic \u00df-lactone.\u00a0Angewandte Chemie International Edition<\/strong><\/em>\u00a052: 1-6.\u00a0pdf<\/a><\/p>\n

Xie Y, Wright S, Shen Y, and Du L. 2012.<\/strong> Bioactive natural products from Lysobacter. Natural Product Reports<\/i>\u00a0<\/strong><\/i>29: 1277-1287.\u00a0pdf<\/a><\/p>\n

Lou L, Chen H, Cerny RL, Li Y, Shen Y, and Du L. 2012.<\/strong> <\/b>Unusual activities of the thioesterase domain for the biosynthesis of the polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes<\/i> C3. <\/i>Biochemistry<\/i><\/strong> <\/i>51, 4-6. pdf<\/a>. (Highlighted on\u00a0<\/span>Biochemistry<\/i><\/span><\/strong> website, January, 2012<\/span>).<\/p>\n

Zhang W, Li Y, Qian G, Wang Y, Chen H, Li Y-Z, Liu F, Shen Y, and\u00a0Du L. 2011.<\/strong> Identification and characterization of the anti-Methicillin-Resistant Staphylococcus aureus<\/i> WAP-8294A2 biosynthetic gene cluster from Lysobacter enzymogenes<\/i> OH11. Antimicrobial Agents and Chemotherapy<\/i><\/strong> 55: 5581-5589.\u00a0pdf.<\/a><\/p>\n

Lou L, Qian G, Xie Y, Hang J, Chen H, Zaleta-Rivera K, Li Y, Shen Y, Dussault PH, Liu F, and\u00a0Du L. 2011.<\/strong> <\/b>Biosynthesis of HSAF, a tetramic acid-containing macrolactam from Lysobacter enzymogenes. <\/i>Journal of the American Chemical Society<\/i><\/strong> <\/i>133: 643-645. pdf<\/a>.<\/p>\n

Du L <\/strong>and\u00a0Lou L. 2010.<\/strong> PKSs and NRPSs release mechanisms. Natural Product Reports<\/i><\/strong> 27: 255-278. pdf<\/a><\/span>.<\/p>\n

Gerber R, Lou L, and Du L. 2009.<\/strong>\u00a0A PLP-dependent polyketide chain releasing mechanism in the biosynthesis of mycotoxin fumonisins in Fusarium verticillioides<\/i>. Journal of the American Chemical Society<\/i><\/strong> <\/i>131: 3148-3149. pdf<\/a>. \u00a0(Highlighted on<\/span> JACS<\/i> <\/span><\/strong>website, March, 2009<\/span>).<\/p>\n

Zhu X, Yu F, Li X-C, and Du L. 2007.<\/strong> Production of dihydroisocoumarins in Fusarium verticillioides<\/i> by swapping the ketosynthase domain of the fungal iterative modular polyketide synthase Fum1p with that of lovastatin diketide synthase. Journal of the American Chemical Society <\/i><\/strong>129: 36-37. pdf<\/a>.<\/p>\n

Yu F, Zaleta-Rivera K, Zhu X, Huffman J, Millet J, Harris SD, Yuen G, Li X, and Du L. 2007.<\/strong> Structure and biosynthesis of HSAF, a broad spectrum antimycotic with a novel mode of action. Antimicrobial Agents and Chemotherapy<\/i><\/strong> 51: 64-72. pdf<\/a>. Cited by<\/span> Faculty of 1000 Biology<\/span> <\/strong>(Evaluated by D. Newman, NIH, March 8,\u00a02007) <\/b>pdf<\/a>.<\/b><\/p>\n

Zaleta-Rivera K, Xu C, Yu F, Butchko RAE, Proctor RH, Lara MEH, Raza A, Dussault PH, and\u00a0Du L.\u00a02006.\u00a0<\/strong>A bidomain nonribosomal peptide synthetase encoded by FUM14<\/i> catalyzes the formation of tricarballylic esters in the biosynthesis of fumonisins.\u00a0Biochemistry<\/i>\u00a0<\/i><\/strong>45: 2561-2569.\u00a0pdf<\/a><\/i><\/b><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

For a complete list of publications, click here For citations and h-index, click here   Selected Recent Publications   Xie X, Li F, Mu Y, Lu M, Luo J, Wang H, Shen Y, Du L, Zhu D, and Li Y. 2025. Structural basis for medium-chain dehydrogenase\/reductase-catalyzed reductive cyclization in polycyclic tetramate macrolactam biosynthesis. Journal of<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":[],"guten_post_layout_featured_media_urls":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"guten_post_layout_landscape_large":false,"guten_post_layout_portrait_large":false,"guten_post_layout_square_large":false,"guten_post_layout_landscape":false,"guten_post_layout_portrait":false,"guten_post_layout_square":false,"featured_image":false,"frontpage_image":false,"custom_header_image":false},"_links":{"self":[{"href":"http:\/\/chemweb.unl.edu\/ldu\/wp-json\/wp\/v2\/pages\/133"}],"collection":[{"href":"http:\/\/chemweb.unl.edu\/ldu\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/chemweb.unl.edu\/ldu\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/chemweb.unl.edu\/ldu\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/chemweb.unl.edu\/ldu\/wp-json\/wp\/v2\/comments?post=133"}],"version-history":[{"count":83,"href":"http:\/\/chemweb.unl.edu\/ldu\/wp-json\/wp\/v2\/pages\/133\/revisions"}],"predecessor-version":[{"id":1465,"href":"http:\/\/chemweb.unl.edu\/ldu\/wp-json\/wp\/v2\/pages\/133\/revisions\/1465"}],"wp:attachment":[{"href":"http:\/\/chemweb.unl.edu\/ldu\/wp-json\/wp\/v2\/media?parent=133"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}